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PubChem
| Name: | Procaine |
|---|---|
| PubChem Compound ID: | 1548986 |
| Description: | A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). |
| Molecular formula: | C13H21N2O2+ |
| Molecular weight: | 237.318 g/mol |
| Synonyms: |
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3/p+; ZINC01530757; 51-05-8
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DrugBank
Identification
| Name: | Procaine |
|---|---|
| Name (isomeric): | DB00721 |
| Drug Type: | small molecule |
| Description: | A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). |
| Synonyms: |
procaine HCl
|
| Brand: | Neocaine, Procaine Hcl, Novocain, Procaine, Base, Nesacaine, Gerovital, Jenacain, Chloroprocaine Hcl, Penicillin G Procaine, Novocaine, P-Aminobenzoyldiethylaminoethanol, Gerovital H-3, Duracillin A.S., Diethylaminoethyl P-Aminobenzoate, Jenacaine, Procaine Hydrochloride, Pfizerpen-As, Duracaine, Procain, Allocaine, Anticort, Spinocaine, Norocaine, Nissocaine, Vitamin H3, Scurocaine |
| Category: | Local Anesthetics, Anesthetics, Anesthetics, Local |
| CAS number: | 59-46-1 |
Pharmacology
| Indication: | Used as a local anesthetic primarily in oral surgery |
|---|---|
| Pharmacology: |
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudoc...
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| Mechanism of Action: |
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium cha...
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| Biotransformation: | Hydrolysis by plasma esterases to PABA |
| Route of elimination: | With normal kidney function, the drug is excreted rapidly by tubular excretion. |
| Half Life: | 7.7 minutes |
| Affected organisms: | Humans and other mammals |
Targets
