QuickView for protease nexin-1 (gene)

Gene Symbol:

SERPINE2 Homo sapiens

Full name:

serpin family E member 2

Synonyms:

GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, glia-derived nexin, glial-derived neurite promoting factor, peptidase inhibitor 7, protease nexin I, serpin E2, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Genomic Location:

Chr 2: 224548118-224612237

Description:

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple...

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This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTAYRTAA_E4BP4_01 ,  CAGGTG_E12_Q6 ,  CREBP1_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

2q36.1

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