QuickView for ryr2 (gene)

Gene Symbol:

RYR2 Homo sapiens

Full name:

ryanodine receptor 2

Synonyms:

ARVC2, ARVD2, RYR-2, RyR, VTSIP, ryanodine receptor 2, cardiac muscle ryanodine receptor-calcium release channel, cardiac-type ryanodine receptor, islet-type ryanodine receptor, kidney-type ryanodine receptor, ryanodine receptor 2 (cardiac), type 2 ryanodine receptor

Genomic Location:

Chr 1: 235272325-236063911

Description:

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with s...

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This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  CTATGCA_MIR153 ,  STAT6_01 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTA_AREB6_01 ,  TGCCTTA_MIR124A ,  GTGCCTT_MIR506 ,  CTGCAGY_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

1q43

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