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QuickView for scopolamine (compound)

Name: Scopolamine
Name (isomeric): DB00747
Drug Type: small molecule
Brand: Hyoscyine Hydrobromide, Hyoscine Bromide, Scopolaminium Bromide, Atroscine Hydrobromide, Transderm-V, Isoscopil, Sereen, Scopamin, Skopolamin, Scopolamine Hydrobromide, Tranaxine, Hyosol, Scopolamine Bromide, Scopolamine Hyoscine, Atroquin, Scopos, Scopolammonium Bromide, Hyocine F Hydrobromide, Scopolamine Hydrobromide Trihydrate, Scopine Tropate, Hyoscine, Epoxytropine Tropate, Transcop, Transderm-Scop, Beldavrin, Atrochin, Triptone, Hyosceine, SEE, Methscopolamine Bromide, Isopto Hyoscine, Tropic Acid, Ester with Scopine, L-Hyoscine Hydrobromide, Hyoscine Hydrobromide, Hysco, Scopoderm-Tts, L-Scopolamine, Hydroscine Hydrobromide, Buscopan, Kwells, Scopolaminhydrobromid, Euscopol, Oscine, Scop
Category: Muscarinic Antagonists, Adjuvants, Anesthesia, Mydriatics, Cholinergic Antagonists, Antispasmodics, Adjuvants, Antimuscarinics
CAS number: 6533-68-2
Indication: For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion ...
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Mechanism of Action: Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Route of elimination: Less than 10% of the total dose is excreted in the urine as parent and metabolites over 108 hours.
Affected organisms: Humans and other mammals
Drug interaction:
TrimethobenzamideTrimethobenzamide and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
DonepezilPossible antagonism of action
TacrineThe therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Scopolamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
TriprolidineTriprolidine and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
CinitaprideAnticholinergic agents like scopolamine may reduce the action of cinitapride.
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