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QuickView for sevoflurane (compound)


PubChem
Name: sevoflurane
PubChem Compound ID: 10176580
Molecular formula: C4H3F7O
Molecular weight: 202.067 g/mol
DrugBank
Identification
Name: sevoflurane
Name (isomeric): DB01236
Drug Type: small molecule
Synonyms:
Sevoflurano [INN-Spanish]; Sevofluranum [INN-Latin]; Sevofluran
Brand: Ultane, Sevorane
Category: Anesthetics, Inhalation, Platelet Aggregation Inhibitors
CAS number: 28523-86-6
Pharmacology
Indication: Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Pharmacology:
Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offs...
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Mechanism of Action:
Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NA...
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Absorption: Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.
Biotransformation: Relatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane.
Route of elimination: The low solubility of sevoflurane facilitates rapid elimination via the lungs. In vivo metabolism studies suggest that approximately 5% of the sevoflurane dose may be metabolized. Up to 3.5% of the sevoflurane dose appears in the urine as inorganic fluoride.
Half Life: 15-23 hours
Toxicity: LC50=49881 ppm/hr (rat), LD50=10.8 g/kg (rat)
Affected organisms: Humans and other mammals

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