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QuickView for sirtuin 1 (gene)


Gene Symbol:
SIRT1 Homo sapiens Homo sapiens
Full name:
sirtuin 1
Synonyms:
SIR2, SIR2L1, SIR2alpha, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, regulatory protein SIR2 homolog 1, sirtuin type 1
Genomic Location:
Chr 10: 69314433-69348149
Description:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and su...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CACTGTG_MIR128A_MIR128B ATGCAGT_MIR217 GTATTAT_MIR3693P AGCYRWTTC_UNKNOWN AAGCCAT_MIR135A_MIR135B USF_Q6 TCANNTGAY_SREBP1_01 ARNT_01 AAAGGGA_MIR204_MIR211 TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-128 Predicted Gene Targets for miR-132 Predicted Gene Targets for miR-135 Predicted Gene Targets for miR-138 Predicted Gene Targets for miR-153 Predicted Gene Targets for miR-181 Predicted Gene Targets for miR-186 Predicted Gene Targets for miR-199 Predicted Gene Targets for miR-141 Predicted Gene Targets for miR-204
Cytogenetic Map:
chr 10
10q21.3





GO Molecular Function

sequence-specific DNA binding | histone deacetylase activity (H3-K9 specific) | kinase binding | transcription regulatory region DNA binding | cofactor binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | keratin filament binding | enhancer binding | NAD+ ADP-ribosyltransferase activity | cation binding | hormone receptor binding | protein kinase binding | enzyme binding | mitogen-activated protein kinase binding | nucleic acid binding | protein-containing complex binding | nucleotide binding | coenzyme binding | signaling receptor binding | hydrolase activity | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein deacetylase activity | NAD+ binding | catalytic activity | protein domain specific binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | enhancer sequence-specific DNA binding | histone deacetylase activity | RNA polymerase II regulatory region DNA binding | p53 binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | identical protein binding | nuclear hormone receptor binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | NAD binding | transferase activity, transferring pentosyl groups | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transferase activity | histone binding | intermediate filament binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | HLH domain binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | NAD-dependent histone deacetylase activity (H3-K9 specific)

GO Biological Process

positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | positive regulation of myeloid cell apoptotic process | negative regulation of TOR signaling | response to extracellular stimulus | negative regulation of phosphorylation | response to radiation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to nutrient levels | positive regulation of cell aging | histone deacetylase activity (H3-K9 specific) | response to cytokine | RNA processing | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | regulation of cholesterol transport | positive regulation of apoptotic process | proteolysis | regulation of localization | positive regulation of histone H3-K9 methylation | gonad development | regulation of carbohydrate metabolic process | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | female gonad development | peptidyl-amino acid modification | regulation of cell aging | regulation of autophagy | regulation of immune system process | response to hormone | myeloid cell differentiation | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | regulation of histone H3-K14 acetylation | histone modification | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | male gamete generation | positive regulation of intrinsic apoptotic signaling pathway | negative regulation of fat cell differentiation | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | histone deacetylation | glucose homeostasis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | response to antibiotic | regulation of lipid transport | regulation of DNA repair | blood vessel morphogenesis | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | organic substance catabolic process | regulation of histone H3-K9 trimethylation | circadian regulation of gene expression | regulation of cell motility | cellular homeostasis | proteolysis involved in cellular protein catabolic process | chromatin organization | establishment of chromatin silencing | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of cholesterol efflux | reproductive system development | positive regulation of adaptive immune response | anion homeostasis | triglyceride metabolic process | regulation of histone H3-K9 methylation | immune system development | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of histone modification | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | response to hypoxia | cellular response to starvation | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | negative regulation of peptidyl-lysine acetylation | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | interspecies interaction between organisms | positive regulation of muscle cell differentiation | muscle structure development | intrinsic apoptotic signaling pathway | negative regulation of histone methylation | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | regulation of bile acid biosynthetic process | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | gene silencing | regulation of metabolic process | catabolic process | regulation of endodeoxyribonuclease activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | negative regulation of oxidative stress-induced cell death | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | regulation of histone H4-K16 acetylation | response to transforming growth factor beta | positive regulation of chromatin silencing | positive regulation of epithelial cell migration | development of primary sexual characteristics | response to UV | stress-induced premature senescence | regulation of histone methylation | regulation of vasculature development | response to stimulus | cellular triglyceride homeostasis | ovulation | vasculature development | female gamete generation | UV-damage excision repair | regulation of cellular protein localization | maintenance of chromatin silencing | regulation of adipose tissue development | regulation of cellular response to heat | regulation of fatty acid biosynthetic process | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | cellular response to light stimulus | positive regulation of phosphatidylinositol 3-kinase signaling | cellular response to hypoxia | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | negative regulation of protein kinase activity | regulation of response to endoplasmic reticulum stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | sterol homeostasis | tube morphogenesis | response to peptide | positive regulation of cysteine-type endopeptidase activity | cholesterol homeostasis | circadian rhythm | response to starvation | ncRNA processing | programmed cell death | development of primary female sexual characteristics | protein destabilization | reproduction | cellular protein catabolic process | cardiovascular system development | peptidyl-lysine acetylation | rhythmic process | positive regulation of proteolysis | regulation of gene silencing | macrophage differentiation | cellular nitrogen compound metabolic process | cellular response to toxic substance | proteasomal protein catabolic process | regulation of macroautophagy | positive regulation of blood vessel endothelial cell migration | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | protein deacetylase activity | pyrimidine dimer repair | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | ovulation from ovarian follicle | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of lipid storage | regulation of steroid metabolic process | histone H3 deacetylation | regulation of TOR signaling | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of histone H4 acetylation | regulation of intracellular transport | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | blood vessel development | DNA repair | regulation of nucleic acid-templated transcription | negative regulation of histone H3-K9 trimethylation | negative regulation of cellular response to transforming growth factor beta stimulus | negative regulation of NF-kappaB transcription factor activity | leukocyte differentiation | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | response to light stimulus | negative regulation of histone H3-K14 acetylation | regulation of macrophage apoptotic process | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | regulation of protein stability | negative regulation of phosphate metabolic process | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | protein acetylation | NAD-dependent protein deacetylase activity | cellular glucose homeostasis | regulation of peptidase activity | single strand break repair | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | positive regulation of chromosome organization | triglyceride mobilization | regulation of gene expression | DNA biosynthetic process | negative regulation of histone H3-K9 methylation | histone deacetylase activity | negative regulation of helicase activity | cellular response to stress | protein catabolic process | regulation of histone H4 acetylation | myeloid leukocyte differentiation | regulation of signal transduction by p53 class mediator | negative regulation of gene expression, epigenetic | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of smooth muscle cell differentiation | pyrimidine dimer repair by nucleotide-excision repair | positive regulation of adipose tissue development | regulation of protein localization to nucleus | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | enzyme linked receptor protein signaling pathway | negative regulation of signal transduction by p53 class mediator | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | negative regulation of cAMP-dependent protein kinase activity | transcription corepressor activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of smooth muscle cell apoptotic process | fat cell differentiation | response to oxidative stress | positive regulation of smooth muscle cell differentiation | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of cholesterol transport | regulation of cAMP-dependent protein kinase activity | positive regulation of cell migration | negative regulation of intracellular steroid hormone receptor signaling pathway | cellular response to cytokine stimulus | biosynthetic process | negative regulation of protein kinase B signaling | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | angiogenesis | regulation of bile acid metabolic process | triglyceride homeostasis | positive regulation of endopeptidase activity | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | response to toxic substance | positive regulation of leukocyte apoptotic process | positive regulation of lipid localization | rRNA metabolic process | leptin-mediated signaling pathway | regulation of apoptotic signaling pathway | cytokine production involved in immune response | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to UV | positive regulation of cellular response to insulin stimulus | NAD-dependent histone deacetylase activity | ovulation cycle process | cellular response to drug | behavioral response to starvation | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | regulation of androgen receptor signaling pathway | histone H3-K9 deacetylation | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | viral process | regulation of lipid biosynthetic process | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | regulation of prostaglandin biosynthetic process | rRNA processing | apoptotic signaling pathway | cell aging | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | positive regulation of molecular function | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | cytokine production | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of MHC class II biosynthetic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | regulation of growth | response to organic substance | neutral lipid metabolic process | protein ubiquitination | regulation of protein import into nucleus | regulation of kinase activity | DNA metabolic process | fatty acid homeostasis | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | response to leptin | response to insulin | anatomical structure development | protein ADP-ribosylation | cell surface receptor signaling pathway | regulation of glucose metabolic process | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | negative regulation of lipid metabolic process | metabolic process | negative regulation of response to oxidative stress | nucleotide-excision repair | negative regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of cAMP-dependent protein kinase activity | regulation of adaptive immune response | regulation of chromatin silencing | regulation of RNA biosynthetic process | macrophage cytokine production | negative regulation of transcription, DNA-templated | negative regulation of histone H4-K16 acetylation | negative regulation of programmed cell death | negative regulation of histone acetylation | peptidyl-lysine modification | cellular response to hydrogen peroxide | chemical homeostasis | positive regulation of cell death | regulation of myeloid cell apoptotic process | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | regulation of response to DNA damage stimulus | immune response | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | response to reactive oxygen species | regulation of endothelial cell proliferation | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | gene expression | chromatin silencing at rDNA | positive regulation of programmed cell death | positive regulation of kinase activity | ion homeostasis | protein modification by small protein conjugation or removal | regulation of cellular response to insulin stimulus | cellular response to ionizing radiation | regulation of phosphate metabolic process | regulation of chromosome organization | positive regulation of autophagy | intrinsic apoptotic signaling pathway by p53 class mediator | transcription, DNA-templated | negative regulation of cell aging | positive regulation of macroautophagy | regulation of brown fat cell differentiation | positive regulation of endothelial cell migration | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of macrophage apoptotic process | negative regulation of cellular response to testosterone stimulus | organonitrogen compound catabolic process | methylation-dependent chromatin silencing | negative regulation of androgen receptor signaling pathway | regulation of cell communication | regulation of peroxisome proliferator activated receptor signaling pathway | regulation of blood vessel endothelial cell migration | negative regulation of chromosome organization | negative regulation of molecular function | cellular senescence | negative regulation of signal transduction | negative regulation of cellular senescence | cellular response to leukemia inhibitory factor | signaling | negative regulation of prostaglandin biosynthetic process | covalent chromatin modification | regulation of transcription, DNA-templated | regulation of epithelial cell proliferation | histone H3-K9 modification | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | reproductive structure development | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of cholesterol efflux | positive regulation of DNA metabolic process | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | positive regulation of cellular senescence | developmental process | organelle organization | regulation of muscle cell differentiation | regulation of cell growth | spermatogenesis | peptidyl-lysine deacetylation | cellular protein modification process | acylglycerol homeostasis | white fat cell differentiation | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of hydrolase activity | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | chromatin silencing | ribonucleoprotein complex biogenesis | positive regulation of histone methylation | positive regulation of lipid transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | female sex differentiation | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | positive regulation of cell motility | modification-dependent protein catabolic process | signal transduction by p53 class mediator | negative regulation of cell death | acylglycerol metabolic process | circulatory system development | aging | carbohydrate homeostasis | negative regulation of fatty acid biosynthetic process | sexual reproduction | positive regulation of angiogenesis | lipid homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | positive regulation of apoptotic signaling pathway | muscle organ development | positive regulation of signaling | negative regulation of fatty acid metabolic process | signal transduction | cellular response to leptin stimulus | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | NAD-dependent histone deacetylase activity (H3-K9 specific) | positive regulation of gene expression | positive regulation of DNA repair | cellular response to growth factor stimulus | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | regulation of cellular senescence | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

nuclear euchromatin | PcG protein complex | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | catalytic complex | rDNA heterochromatin | organelle membrane | nuclear membrane | cell | nuclear lumen | nuclear transcriptional repressor complex | nuclear inner membrane | ESC/E(Z) complex | nucleolus | cytoplasm | intracellular organelle | nuclear body | histone methyltransferase complex | euchromatin | protein-containing complex | PML body | methyltransferase complex | endomembrane system | nucleoplasm | nuclear envelope | chromatin | nuclear chromosome | transferase complex | mitochondrion | membrane-bounded organelle | transcriptional repressor complex | heterochromatin | nucleus | organelle | nuclear heterochromatin | membrane-enclosed lumen | nuclear chromatin | chromatin silencing complex | cytosol | intracellular | membrane