Name: | Streptozocin |
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PubChem Compound ID: | 169966 |
Description: | An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. |
Molecular formula: | C8H15N3O7 |
Molecular weight: | 265.221 g/mol |
Synonyms: |
2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-galactose; 37793-01-4; D-Galactose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
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Name: | Streptozocin |
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Name (isomeric): | DB00428 |
Drug Type: | small molecule |
Description: | An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. |
Brand: | Streptozocinum [INN-Latin], Streptozoticin, Zanosar, STZ, Streptozocinium [Latin], STREPTOZOTOCIN, Streptozocine [INN-French], Streptozocin [Usan:Inn], STRZ |
Category: | Antineoplastic Agents, Antibiotics, Antibiotics, Antineoplastic |
CAS number: | 18883-66-4 |
Indication: | For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma). |
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Pharmacology: |
Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine...
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Mechanism of Action: |
Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular...
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Absorption: | Poor oral absorption (17-25%) |
Biotransformation: | Primarily hepatic |
Route of elimination: | As much as 20% of the drug (or metabolites containing an N-nitrosourea group) is metabolized and/or excreted by the kidney. |
Half Life: | 5-15 minutes |
Toxicity: | Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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