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QuickView for sulfamethizole (compound)


PubChem
Name: Sulfamethizole
PubChem Compound ID: 5328
Description: A sulfathiazole antibacterial agent.
Molecular formula: C9H10N4O2S2
Molecular weight: 270.333 g/mol
Synonyms:
MLS000028603; Urolucosil; AI3-50149; CAS-144-82-1; Sulfamethizole (JP15/USP); D00870; Sulfstat; Spectrum2_001322; Spectrum4_000640; Renasul.
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DrugBank
Identification
Name: Sulfamethizole
Name (isomeric): DB00576
Drug Type: small molecule
Description: A sulfathiazole antibacterial agent.
Brand: Sulfamethazole, Microsul, Sulfametizol [INN-Spanish], Urosulfin, Sulfa Gram, Lucosil, Sulfamethylthiadiazole, Sulfurine, Famet, Sulfamethizolum [INN-Latin], Ultrasul, Sulfamethiazole, Sulfamethizol, Sulphamethizole, Urolucosil, Sulfamethizole [Usan:Inn:Jan], Tetracid, Sulfstat, Urocydal, Urodiaton, Ayerlucil, Thidicur, Solfametizolo [Dcit], Sulfapyelon, Thiosulfil, Uroz, Sulamethizole, Sulphamethyltiadiazole, Methazol, Thiosulfil Forte, Rufol, Proklar, Salimol, Renasul
Category: Anti-Infective Agents, Anti-Infectives
CAS number: 144-82-1
Pharmacology
Indication: For the treatment of urinary tract infection
Pharmacology:
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-amino...
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Mechanism of Action: Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Absorption: Rapidly absorbed.
Protein binding: 98-99%
Biotransformation: Hepatic.
Half Life: 3-8 hours
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
Methenamine mandelatePossible crystallization of urates with this combination
PhenytoinThe sulfonamide increases the effect of hydantoin
FosphenytoinThe sulfonamide increases the effect of hydantoin
ChlorpropamideSulfonamide/sulfonylurea: possible hypoglycemia
MethotrexateThe sulfamide increases the toxicity of methotrexate

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