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QuickView for sulfasalazine (compound)


PubChem
Name: Sulfasalazine
PubChem Compound ID: 5353980
Description: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Molecular formula: C18H14N4O5S
Molecular weight: 398.394 g/mol
Synonyms:
5-22-08-00433 (Beilstein Handbook Reference); AIDS-059756; Prestwick1_000520; 599-79-1; Salicylic acid, 5-((p-(2-pyridylsulfamoyl)phenyl)azo)-; S.A.S.-500; SASP; CCRIS 4713; HSDB 3395; W-T Sasp Oral.
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DrugBank
Identification
Name: Sulfasalazine
Name (isomeric): DB00795
Drug Type: small molecule
Description: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Synonyms:
Sulphasalazine; Sulfasalazin
Brand: Azopyrine, Salisulf, Azopyrin, Salazosulfapyridine, Salazopiridazin, Rorasul, Azulfidine, Azlufidine EN-Tabs, Asulfidine, Salazopyrin EN-Tabs, S.A.S. Enteric-500, PMS-Sulfasalazine, Salazosulfapyridin, Sulcolon, Benzosulfa, W-T Sasp Oral, Salicylazosulfapyridine, Colo-Pleon, Azulfidine EN-Tabs, Salazopyridin, Reupirin, Alti-Sulfasalazine, Salazopyrin, Accucol, Pms-Sulfasalazine E.C.
Category: Anti-Infective Agents, Gastrointestinal Agents, Antirheumatic Agents, Sulfonamides
CAS number: 599-79-1
Pharmacology
Indication: For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Pharmacology: Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.
Mechanism of Action:
The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high ...
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Route of elimination: The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.
Half Life: 5-10 hours
Clearance: 1 L/h [IV administration]
Affected organisms: Humans and other mammals
Interactions
Food interaction:
May take Vitamin D.
Take with a full glass of water No iron, zinc or fluoride within 2 hours of taking this medication.
Take with food.
Drug interaction:
ThioguanineSulfasalazine may increase the toxicity of thiopurine, thioguanine.
CyclosporineThe sulfonamide decreases the effect of cyclosporine
ChlorpropamideSulfonamide/sulfonylurea: possible hypoglycemia
DigoxinSulfasalazine may decrease the effect of digoxin.
MercaptopurineSulfasalazine may increase the toxicity of thiopurine, mercaptopurine.
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