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PubChem
Name: Suramin
PubChem Compound ID: 5361
Description: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Molecular formula: C51H40N6O23S6
Molecular weight: 1297.29 g/mol
Synonyms:
NSC34936; Naganil; sym-bis(m-aminobenzoyl-m-amino-p-methylbenzoyl-1-napthylamino-4,6,8-trisulfonate) carbamide; Naganin; 1,3,5-Naphthylenetrisulfonic acid, 8,8'-(ureylenebis(m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino))di-; Carbanilide, 3,3'-bis((5-((4,6,8-trisulfo-1-naphthyl)carbamoyl)-o-tolyl)carbamoyl)-; Harnstoff, symmetischer der 3-aminobenzoyl-3-amino-4-methylbenzoyl-1-naphthylamin-4,6,8-trisulfonsaeure; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-; Spectrum4_001247; Sodium suramin.
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DrugBank
Identification
Name: Suramin
Name (isomeric): DB04786
Drug Type: small molecule
Description: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Synonyms:
Sodium suramin; Suramine sodium; Bayer 205; Suramine; Suramin sodium; SVR
Brand: Moranyl, Germanin, Naphuride, Farma, Belganyl, Naganine, Fourneau, Naganin, Antrypol, Naganol, Naganil
Category: Trypanocidal Agents, Antineoplastic Agents, Antinematodal Agents
CAS number: 145-63-1
Pharmacology
Indication: For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
Mechanism of Action:
The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocercias...
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Absorption: Poorly absorbed from the gastrointestinal tract.
Protein binding: Approximately 99.7%
Biotransformation: Little or no metabolism
Half Life: Approximately 36 to 60 days
Affected organisms: Yeast, Molds, Trypanosomes

Targets