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QuickView for tagL (gene)


Gene Symbol:
PGLYRP2 Homo sapiens Homo sapiens
Full name:
peptidoglycan recognition protein 2
Synonyms:
HMFT0141, PGLYRPL, PGRP-L, PGRPL, TAGL-like, tagL, tagL-alpha, tagl-beta, N-acetylmuramoyl-L-alanine amidase, peptidoglycan recognition protein L, peptidoglycan recognition protein long
Genomic Location:
Chr 19: 15440456-15451315
Description:
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologicall...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.12


Transcripts Names
NM_052890
XM_006722633



GO Molecular Function

N-acetylmuramoyl-L-alanine amidase activity | cation binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | peptidoglycan receptor activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | signaling receptor activity | ion binding | signaling pattern recognition receptor activity | peptidoglycan binding | zinc ion binding | glycosaminoglycan binding | transition metal ion binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding

GO Biological Process

positive regulation of immune response | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | negative regulation of immune system process | detection of stimulus | immune response-regulating signaling pathway | defense response to other organism | regulation of immune system process | negative regulation of cellular process | defense response | peptidoglycan catabolic process | innate immune response-activating signal transduction | cellular process | organic substance catabolic process | carbohydrate derivative catabolic process | glycosaminoglycan catabolic process | regulation of cell differentiation | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | catabolic process | regulation of natural killer cell activation | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | negative regulation of lymphocyte activation | negative regulation of interferon-gamma production | activation of innate immune response | cellular nitrogen compound metabolic process | immune response-activating signal transduction | growth of symbiont in host | negative regulation of hemopoiesis | regulation of lymphocyte differentiation | peptidoglycan receptor activity | response to external biotic stimulus | nitrogen compound metabolic process | pattern recognition receptor signaling pathway | negative regulation of cytokine production | regulation of lymphocyte activation | cellular amide metabolic process | negative regulation of immune response | peptidoglycan metabolic process | response to bacterium | cell communication | negative regulation of natural killer cell differentiation involved in immune response | signaling pattern recognition receptor activity | negative regulation of cell activation | humoral immune response | defense response to bacterium | negative regulation of natural killer cell activation | peptide metabolic process | peptide modification | antimicrobial humoral response | regulation of natural killer cell differentiation involved in immune response | activation of immune response | regulation of innate immune response | regulation of hemopoiesis | metabolic process | immune response | organic substance metabolic process | regulation of cell activation | detection of bacterium | peptide amidation | organonitrogen compound catabolic process | regulation of natural killer cell differentiation | defense response to Gram-positive bacterium | signaling | regulation of cytokine production | response to biotic stimulus | regulation of developmental process | detection of biotic stimulus | carbohydrate derivative metabolic process | innate immune response | regulation of interferon-gamma production | immune system process | cellular metabolic process | regulation of inflammatory response | negative regulation of cell differentiation | response to other organism | signal transduction | glycosaminoglycan metabolic process | macromolecule metabolic process

GO Cellular Component

cell | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular | membrane