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Gene Symbol:
TERT Homo sapiens Homo sapiens
Full name:
telomerase reverse transcriptase
Synonyms:
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase-associated protein 2
Genomic Location:
Chr 5: 1306282-1348162
Description:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence,...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5p15.33





GO Molecular Function

sequence-specific DNA binding | telomerase RNA binding | cation binding | nucleic acid binding | 5'-3' RNA polymerase activity | tRNA binding | telomerase activity | transcription coactivator binding | DNA polymerase activity | nucleotidyltransferase activity | catalytic activity | chaperone binding | protein N-terminus binding | DNA binding | identical protein binding | RNA-directed 5'-3' RNA polymerase activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | transcription factor binding | protein dimerization activity | telomerase RNA reverse transcriptase activity | transferase activity, transferring phosphorus-containing groups | template-free RNA nucleotidyltransferase | transferase activity | RNA-directed DNA polymerase activity | transcription cofactor binding | metal ion binding | heterocyclic compound binding | telomeric DNA binding | protein C-terminus binding | RNA binding

GO Biological Process

RNA metabolic process | gene silencing by RNA | positive regulation of smooth muscle cell proliferation | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | telomere maintenance | regulation of production of siRNA involved in RNA interference | RNA processing | regulation of neurogenesis | regulation of cellular localization | regulation of cell development | regulation of localization | regulation of cell cycle G1/S phase transition | positive regulation of G1/S transition of mitotic cell cycle | regulation of programmed cell death | regulation of cell aging | negative regulation of glial cell proliferation | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | negative regulation of production of siRNA involved in RNA interference | positive regulation of developmental process | response to metal ion | cell differentiation | nervous system development | production of small RNA involved in gene silencing by RNA | regulation of G1/S transition of mitotic cell cycle | neurogenesis | negative regulation of gene silencing by RNA | positive regulation of cellular component movement | regulation of RNA interference | generation of neurons | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | telomere maintenance via telomerase | negative regulation of gliogenesis | regulation of glucose import | regulation of cell motility | localization | negative regulation of signaling | dsRNA fragmentation | regulation of protein localization to nucleolus | positive regulation of nitric-oxide synthase activity | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | positive regulation of oxidoreductase activity | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | anatomical structure homeostasis | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | gene silencing | regulation of metabolic process | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | RNA biosynthetic process | positive regulation of hair cycle | cellular aromatic compound metabolic process | cellular component organization | positive regulation of protein binding | regulation of vasculature development | response to stimulus | negative regulation of epithelial cell apoptotic process | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | telomerase activity | cellular response to hypoxia | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of transdifferentiation | positive regulation of glucose import | regulation of cell cycle phase transition | regulation of smooth muscle cell migration | beta-catenin-TCF complex assembly | DNA polymerase activity | cellular localization | regulation of gene silencing | cellular nitrogen compound metabolic process | telomere organization | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | mitochondrion organization | telomere maintenance via telomere lengthening | positive regulation of vascular associated smooth muscle cell migration | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | positive regulation of monooxygenase activity | response to nitrogen compound | negative regulation of neuron apoptotic process | system development | RNA interference | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | multicellular organism development | response to dsRNA | positive regulation of smooth muscle cell migration | regulation of catalytic activity | regulation of nitric-oxide synthase activity | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | DNA biosynthetic process | regulation of extrinsic apoptotic signaling pathway | cellular response to stress | regulation of stem cell proliferation | RNA-dependent DNA biosynthetic process | positive regulation of cellular metabolic process | regulation of pri-miRNA transcription by RNA polymerase II | establishment of protein localization to chromosome | regulation of protein localization to nucleus | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of endothelial cell apoptotic process | protein localization to organelle | positive regulation of cell differentiation | RNA-directed 5'-3' RNA polymerase activity | negative regulation of extrinsic apoptotic signaling pathway | positive regulation of cell migration | positive regulation of glucose transmembrane transport | positive regulation of protein localization to nucleus | biosynthetic process | response to cadmium ion | aromatic compound biosynthetic process | positive regulation of pri-miRNA transcription by RNA polymerase II | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | positive regulation of cell cycle G1/S phase transition | DNA strand elongation | posttranscriptional gene silencing | regulation of cellular metabolic process | regulation of neuron apoptotic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of glial cell proliferation | positive regulation of signal transduction | cellular response to dsRNA | homeostatic process | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | cell aging | regulation of mitotic cell cycle | positive regulation of molecular function | negative regulation of gene silencing | protein-containing complex assembly | posttranscriptional gene silencing by RNA | response to organic substance | positive regulation of protein localization to nucleolus | protein localization to chromosome, telomeric region | DNA metabolic process | replicative senescence | establishment of protein localization to organelle | anatomical structure development | telomerase RNA reverse transcriptase activity | positive regulation of mitotic cell cycle phase transition | metabolic process | regulation of RNA biosynthetic process | negative regulation of RNA interference | negative regulation of programmed cell death | cellular protein localization | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | regulation of glucose transmembrane transport | gene expression | regulation of Wnt signaling pathway | positive regulation of binding | establishment of protein localization | negative regulation of cell aging | transcription, RNA-templated | regulation of cell communication | regulation of gliogenesis | establishment of protein localization to telomere | negative regulation of signal transduction | negative regulation of cellular senescence | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of protein binding | response to organic cyclic compound | protein localization | regulation of production of small RNA involved in gene silencing by RNA | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of stem cell proliferation | RNA-directed DNA polymerase activity | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | positive regulation of cell cycle process | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of hair cycle | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of Wnt signaling pathway | cellular metabolic process | production of siRNA involved in RNA interference | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | negative regulation of cell death | negative regulation of cell development | aging | positive regulation of angiogenesis | negative regulation of cell differentiation | positive regulation of signaling | protein localization to chromosome | regulation of signaling | negative regulation of endothelial cell apoptotic process | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | regulation of cellular senescence | multicellular organismal process

GO Cellular Component

mitochondrial matrix | nuclear telomere cap complex | chromosome | intracellular membrane-bounded organelle | catalytic complex | RNA-directed RNA polymerase complex | telomerase catalytic core complex | cell | nuclear lumen | nucleolus | mitochondrial nucleoid | cytoplasm | nucleoid | intracellular organelle | nuclear body | protein-containing complex | PML body | protein-DNA complex | telomere cap complex | nucleoplasm | plasma membrane | nuclear chromosome | nuclear speck | ribonucleoprotein complex | transferase complex | mitochondrion | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | cell periphery | RNA polymerase complex | membrane-enclosed lumen | TERT-RMRP complex | telomerase holoenzyme complex | cytosol | nuclear chromosome, telomeric region | intracellular | membrane