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Gene Symbol:
CUBN Homo sapiens Homo sapiens
Full name:
cubilin
Synonyms:
IFCR, MGA1, gp280, cubilin, 460 kDa receptor, cubilin (intrinsic factor-cobalamin receptor), cubilin precursor variant 1, cubilin precursor variant 2, cubilin precursor variant 3, intestinal intrinsic factor receptor, intrinsic factor-vitamin B12 receptor
Genomic Location:
Chr 10: 16905971-17211822
Description:
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10p13





GO Molecular Function

cofactor binding | channel regulator activity | cation binding | hemoglobin binding | vitamin binding | molecular function regulator | signaling receptor activity | transporter activity | identical protein binding | ion binding | organic cyclic compound binding | tetrapyrrole binding | protein binding | protein homodimerization activity | protein dimerization activity | cobalamin binding | calcium ion binding | drug binding | metal ion binding | heterocyclic compound binding | cargo receptor activity | small molecule binding

GO Biological Process

response to extracellular stimulus | protein homooligomerization | high-density lipoprotein particle clearance | response to nutrient levels | hyperosmotic response | cobalamin metabolic process | cell-cell signaling involved in cell fate commitment | establishment of localization | cell differentiation | response to drug | tissue homeostasis | sterol metabolic process | cellular process | organic substance catabolic process | channel regulator activity | localization | positive regulation of synaptic transmission | protein transport | macromolecule localization | anatomical structure homeostasis | regulation of cellular process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | response to stress | alcohol metabolic process | multicellular organismal homeostasis | regulation of plasma lipoprotein particle levels | protein homotrimerization | cellular localization | cellular nitrogen compound metabolic process | lipoprotein transport | cofactor metabolic process | cellular component assembly | modulation of chemical synaptic transmission | positive regulation of synaptic transmission, glutamatergic | embryo development | cell-cell signaling | drug catabolic process | molecular function regulator | locomotion | organic hydroxy compound metabolic process | response to external biotic stimulus | nitrogen compound metabolic process | multicellular organism development | thigmotaxis | regulation of synaptic transmission, glutamatergic | endocytic hemoglobin import | protein complex oligomerization | vitamin transport | lipid metabolic process | organic substance transport | adult locomotory behavior | small molecule metabolic process | peptide transport | vesicle-mediated transport | cobalamin catabolic process | response to nutrient | protein localization to organelle | locomotory behavior | response to osmotic stress | plasma lipoprotein particle clearance | protein import | response to bacterium | chordate embryonic development | cell communication | protein trimerization | aromatic compound catabolic process | homeostatic process | regulation of locomotion | embryo development ending in birth or egg hatching | drug metabolic process | protein-containing complex assembly | vitamin metabolic process | import into cell | establishment of protein localization to organelle | anatomical structure development | cofactor transport | lateral inhibition | metabolic process | cell fate commitment | cholesterol metabolic process | cellular protein localization | amide transport | endocytosis | behavior | organic substance metabolic process | establishment of protein localization | drug transport | adult behavior | organonitrogen compound catabolic process | steroid metabolic process | regulation of cell communication | cobalamin transport | signaling | protein localization | cellular macromolecule localization | response to biotic stimulus | heme transport | receptor-mediated endocytosis | developmental process | heterocycle metabolic process | in utero embryonic development | cargo receptor activity | cellular metabolic process | vitamin D metabolic process | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

brush border | integral component of membrane | intracellular membrane-bounded organelle | synapse | apical plasma membrane | neuron projection | extrinsic component of membrane | endocytic vesicle membrane | organelle membrane | cell projection membrane | cytoplasmic vesicle | cell | plasma membrane protein complex | extrinsic component of plasma membrane | vacuolar lumen | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | brush border membrane | leading edge membrane | apical part of cell | endosome membrane | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | plasma membrane | Golgi-associated vesicle | cell leading edge | vacuole | vesicle | clathrin-coated pit | extracellular exosome | lytic vacuole | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | lysosome | extracellular space | cell periphery | extrinsic component of external side of plasma membrane | membrane-enclosed lumen | ionotropic glutamate receptor complex | lysosomal lumen | transmembrane transporter complex | ion channel complex | cytosol | intracellular vesicle | cell surface | endocytic vesicle | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | neuron projection membrane | intrinsic component of plasma membrane | vacuolar membrane | coated vesicle