transcription coregulator activity QuickView

Description:: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coregulator (specifically, a coactivator).
Taxonomy/Path:: GO : transcription regulator activity / transcription coregulator activity