Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Taxonomy/Path:
GO : transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding / transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding