QuickView for transgelin (gene)

Gene Symbol:

TAGLN Homo sapiens

Full name:

transgelin

Synonyms:

SM22, SM22-alpha, SMCC, TAGLN1, WS3-10, transgelin, 22 kDa actin-binding protein, smooth muscle protein 22-alpha, transgelin variant 2

Genomic Location:

Chr 11: 116575250-116580718

Description:

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It act...

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This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRF_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  TATA_C ,  SRF_Q4 ,  CTTTAAR_UNKNOWN ,  GGCAGCT_MIR22 ,  SRF_Q5_01 ,  SMAD_Q6 ,  SP1_Q6_01 ,  TGACATY_UNKNOWN ,  CCAWWNAAGG_SRF_Q4 ,  SRF_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-485-5p

Cytogenetic Map:

11q23.3

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