Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for triiodothyronine (compound)


PubChem
Name: Triiodothyronine
PubChem Compound ID: 5920
Description: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Molecular formula: C15H12I3NO4
Molecular weight: 650.974 g/mol
Synonyms:
L-3,5,3'-Triiodothyronine; THYROID HORMONE; Liothyronine I 131; 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine; Tresitope; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-; L-Liothyronine; Liothyronine; Triiodothyronine, l-; NCGC00013556.
show more »
DrugBank
Identification
Name: Triiodothyronine
Name (isomeric): DB00279
Drug Type: small molecule
Description: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Synonyms:
Liothyronin; L-Liothyronine; Triiodothyronine; Liothyronine Sodium; T3 liothyronine
Brand: Tertroxin, Triostat, Cytomel, Tresitope
Brand name mixture: Liotrix(Levothyroxine + Liothyronine), Thyrolar(Levothyroxine + Liothyronine)
Category: Hormone Replacement Agents
CAS number: 6893-02-3
Pharmacology
Indication: Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis.
Pharmacology:
Thyroid hormone drugs are natural or synthetic preparations containing T4 or T3 or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. Liothyronine (T3) contains three atoms of iodine and is formed by the coupling of one molecule of...
show more »
Mechanism of Action:
The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid hormone in the blood is thyroxine (T4). This is converted to the more active liothyronine form by deiodinases in peripheral tissues. Liothyronine acts on the body to...
show more »
Absorption: 95% in 4 hours
Protein binding: 99.7%
Half Life: 2.5 days
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
Calcium ChlorideCalcium salts such as calcium chloride may diminish the therapeutic effect of thyroid products such as liothyronine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
DigoxinThe thyroid hormone, liothyronine, decreases the effect of digoxin.
Calcium AcetateCalcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as liothyronine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
ColestipolThe resin, colestipol, decreases the absorption of the thyroid hormone, liothyronine.
WarfarinLiothyronine may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if liothyronine is initiated, discontinued or dose changed.
show more »

Targets


Transporters


Carriers