Name: | Triiodothyronine |
---|---|
PubChem Compound ID: | 5920 |
Description: | A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. |
Molecular formula: | C15H12I3NO4 |
Molecular weight: | 650.974 g/mol |
Synonyms: |
L-3,5,3'-Triiodothyronine; THYROID HORMONE; Liothyronine I 131; 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine; Tresitope; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-; L-Liothyronine; Liothyronine; Triiodothyronine, l-; NCGC00013556.
show more » |
Name: | Triiodothyronine |
---|---|
Name (isomeric): | DB00279 |
Drug Type: | small molecule |
Description: | A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. |
Synonyms: |
Liothyronin; L-Liothyronine; Triiodothyronine; Liothyronine Sodium; T3 liothyronine
|
Brand: | Tertroxin, Triostat, Cytomel, Tresitope |
Brand name mixture: | Liotrix(Levothyroxine + Liothyronine), Thyrolar(Levothyroxine + Liothyronine) |
Category: | Hormone Replacement Agents |
CAS number: | 6893-02-3 |
Indication: | Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis. |
---|---|
Pharmacology: |
Thyroid hormone drugs are natural or synthetic preparations containing T4 or T3 or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. Liothyronine (T3) contains three atoms of iodine and is formed by the coupling of one molecule of...
show more » |
Mechanism of Action: |
The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid hormone in the blood is thyroxine (T4). This is converted to the more active liothyronine form by deiodinases in peripheral tissues. Liothyronine acts on the body to...
show more » |
Absorption: | 95% in 4 hours |
Protein binding: | 99.7% |
Half Life: | 2.5 days |
Affected organisms: | Humans and other mammals |
Drug interaction: |
|
---|