Name: | Tryptophan |
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PubChem Compound ID: | 10130455 |
Description: | An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. |
Molecular formula: | C11H12N2O2 |
Molecular weight: | 205.218 g/mol |
Name: | Tryptophan |
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Name (isomeric): | DB00150 |
Drug Type: | small molecule |
Description: | An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. |
Synonyms: |
alpha-Amino-beta-(3-indolyl)-propionic acid; Tryptophane; (S)-Tryptophan; 3-Indol-3-ylalanine; Tryptophan; (-)-Tryptophan; L-(-)-Tryptophan; l-b-3-Indolylalanine; (S)-a-Amino-1H-indole-3-propanoic acid; 2-Amino-3-indolylpropanoic acid.
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Brand: | Lyphan, Alti-Tryptophan |
Category: | Micronutrient, Dietary supplement, Essential Amino Acids, Antidepressive Agents, Second-Generation |
CAS number: | 73-22-3 |
Indication: | Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight. |
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Pharmacology: |
Tryptophan is critical for the production of the body's proteins, enzymes and muscle tissue. It is also essential for the production of niacin, the synthesis of the neurotransmitter serotonin and melatonin. Tryptophan supplements can be used as natural relaxants to help relieve insomnia. Tryptophan can also reduce anxiety and depression and has bee...
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Mechanism of Action: |
A number of important side reactions occur during the catabolism of tryptophan on the pathway to acetoacetate. The first enzyme of the catabolic pathway is an iron porphyrin oxygenase that opens the indole ring. The latter enzyme is highly inducible, its concentration rising almost 10-fold on a diet high in tryptophan. Kynurenine is the first key b...
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Biotransformation: | Hepatic. |
Toxicity: | Oral rat LD50: > 16 gm/kg. Investigated as a tumorigen, mutagen, reproductive effector. Symptoms of overdose include agitation, confusion, diarrhea, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, talking or acting with excitement you cannot control, trembling or shaking, twitching, and vomiting. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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