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QuickView for tumor necrosis factor receptor 1 (gene)


Gene Symbol:
Tnfrsf1a Mus musculus Mus musculus
Full name:
tumor necrosis factor receptor superfamily, member 1a
Synonyms:
CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R, tumor necrosis factor receptor superfamily member 1A, TNF receptor alpha chain, TNF-RI, TNF-alpha-R1, TNFR-I, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor type I
Genomic Location:
Chr 6: 125299773-125312503
Description:
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_011609
Protein Names
P25118
Q3U479



GO Molecular Function

cytokine binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | tumor necrosis factor binding | death receptor activity | signaling receptor activity | identical protein binding | protein binding | tumor necrosis factor-activated receptor activity | protease binding

GO Biological Process

regulation of muscle system process | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to cytokine | protein localization to cell periphery | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | negative regulation of cellular process | positive regulation of developmental process | cellular response to tumor necrosis factor | regulation of protein import | defense response | intrinsic apoptotic signaling pathway in response to DNA damage | regulation of extracellular matrix organization | pulmonary valve development | positive regulation of phosphate metabolic process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | localization | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | intrinsic apoptotic signaling pathway | negative regulation of muscle hypertrophy | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | cellular lipid metabolic process | positive regulation of tumor necrosis factor production | regulation of vasculature development | response to stimulus | regulation of cellular protein localization | monocarboxylic acid metabolic process | regulation of peptidyl-tyrosine phosphorylation | negative regulation of extracellular matrix organization | positive regulation of protein metabolic process | response to stress | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | regulation of epithelial cell differentiation | programmed cell death | cellular localization | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of peptide transport | regulation of intracellular transport | regulation of nucleic acid-templated transcription | apoptotic process | response to external biotic stimulus | system development | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of interleukin-6 production | multicellular organism development | positive regulation of inflammatory response | cellular response to DNA damage stimulus | protein complex oligomerization | lipid metabolic process | regulation of phosphorylation | protein localization to plasma membrane | regulation of gene expression | protein localization to membrane | cellular response to stress | death receptor activity | positive regulation of intracellular protein transport | negative regulation of cytokine production | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | negative regulation of cardiac muscle hypertrophy | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | negative regulation of extracellular matrix constituent secretion | cellular response to cytokine stimulus | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | positive regulation of neuron death | regulation of tumor necrosis factor production | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of tyrosine phosphorylation of STAT protein | regulation of establishment of endothelial barrier | semi-lunar valve development | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | heart development | defense response to bacterium | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | apoptotic signaling pathway | positive regulation of apoptotic process involved in development | carboxylic acid metabolic process | regulation of nucleocytoplasmic transport | protein-containing complex assembly | heart valve development | regulation of cardiac muscle hypertrophy | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of protein import into nucleus | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | cellular protein localization | prostaglandin metabolic process | regulation of secretion | positive regulation of cell death | organic substance metabolic process | cell death | negative regulation of gene expression | tumor necrosis factor-activated receptor activity | animal organ development | positive regulation of programmed cell death | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | fatty acid metabolic process | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of protein transport | icosanoid metabolic process | positive regulation of protein import into nucleus, translocation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | protein localization | organic acid metabolic process | positive regulation of phosphorylation | regulation of cytokine production | protein heterooligomerization | cellular macromolecule localization | positive regulation of protein import into nucleus | response to biotic stimulus | regulation of developmental process | developmental process | positive regulation of protein import | regulation of transport | positive regulation of transcription, DNA-templated | aortic valve development | regulation of endothelial cell differentiation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of apoptotic process involved in development | positive regulation of metabolic process | cellular metabolic process | response to tumor necrosis factor | positive regulation of apoptotic process involved in morphogenesis | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | regulation of interleukin-6 production | circulatory system development | regulation of inflammatory response | positive regulation of nucleocytoplasmic transport | positive regulation of angiogenesis | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | synapse | neuron projection | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | plasma membrane | membrane raft | mitochondrion | Golgi membrane | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | axon | cytosol | cell surface | intracellular | membrane