QuickView for usp45 (gene)

Gene Symbol:

USP45 Homo sapiens

Full name:

ubiquitin specific peptidase 45

Synonyms:

ubiquitin carboxyl-terminal hydrolase 45, deubiquitinating enzyme 45, ubiquitin specific protease 45, ubiquitin thioesterase 45, ubiquitin thiolesterase 45, ubiquitin-specific-processing protease 45

Genomic Location:

Chr 6: 99986903-100069973

Description:

The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1.

The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

6q16.2

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