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QuickView for vancomycin (compound)


PubChem
Name: Vancomycin
PubChem Compound ID: 11947756
Description: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Molecular formula: C66H76Cl3N9O24
Molecular weight: 1485.71 g/mol
DrugBank
Identification
Name: Vancomycin
Name (isomeric): DB00512
Drug Type: small molecule
Description: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Synonyms:
Vancomycin HCL
Brand: Vancoled, Vancor, Vancocin HCL, Vancocin
Category: Anti-Bacterial Agents, Glycopeptide antibacterials
CAS number: 1404-90-6
Pharmacology
Indication: For the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci.
Pharmacology:
Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the fermentation of the Actinobacteria species Amycolatopsis orientalis (formerly Nocardia orientalis). It is often reserved as the "drug of last resort", used only after treatment with other antibiotics had failed. Vancomycin has been shown to be active ...
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Mechanism of Action:
The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls...
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Absorption: Poorly absorbed from gastrointestinal tract, however systemic absorption (up to 60%) may occur following intraperitoneal administration.
Protein binding: Approximately 55% serum protein bound.
Route of elimination: In the first 24 hours, about 75% of an administered dose of vancomycin is excreted in urine by glomerular filtration.
Half Life: Half-life in normal renal patients is approximately 6 hours (range 4 to 11 hours). In anephric patients, the average half-life of elimination is 7.5 days.
Clearance: 0.06 L/kg/h
Toxicity: The oral LD50 in mice is 5000 mg/kg. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
ColistimethateAdditive nephrotoxic effects may occur. Consider alternate therapy or monitor for renal function during concomitant therapy.
Gallium nitrateAdditive nephrotoxic effects may occur. Avoid concomitant therapy.
TobramycinIncreased risk of nephrotoxicity

Targets


Transporters