BaseSpace

Correlation
Engine-Public

Correlation Engine 2.0

Home
My Data
Bookmarks
Collaborations
Inbox

Import Your Data

QuickView

FAQ

What is QuickView?
What can my QuickView results tell me?
What are the sources for the General Info tab in QuickView?

More QuickView FAQs

QuickView

Curated
Studies
Body
Atlas
Disease
Atlas
Pharmaco
Atlas
Knockdown
Atlas
Genetic
Markers
Pathway
Enrichment

Literature
Clinical
Trials

0
Meta-
Analysis

Search sequence regions

(e.g. Amniocentesis, Trichostatin A, rs3825942, FXYD4, Apoptosis, Influenza, Intestine)

Organisms	Chromosomes	Start	Stop

Go back to main search

Bookmark Forward

QuickView for vitamin B3 (compound)

Summary
General Info

PubChem

PubChem Compound 11159323

Name:	Niacinamide
PubChem Compound ID:	11159323
Description:	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Molecular formula:	C₆H₆N₂O
Molecular weight:	124.124 g/mol

DrugBank

Identification

Name:	Niacinamide
Name (isomeric):	DB02701
Drug Type:	small molecule
Description:	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Category:	Vitamin B Complex
CAS number:	98-92-0

Targets

Exotoxin A

This toxin is a NAD-dependent ADP-ribosyltransferase. It catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD onto elongation factor 2 (EF-2) thus arresting protein synthesis

UniProt ID:

P11439

Gene:

eta

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

L-lactate dehydrogenase A chain

UniProt ID:

P00338

Gene:

LDHA

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Poly [ADP-ribose] polymerase 1

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks

UniProt ID:

P09874

Gene:

PARP1

Actions:

binder

References:

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
View Article

NAD-dependent deacetylase sirtuin-5

Probable NAD-dependent deacetylase (By similarity)

UniProt ID:

Q9NXA8

Gene:

SIRT5

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

ADP-ribosyl cyclase 2

Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth

UniProt ID:

Q10588

Gene:

BST1

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Enzymes

Cytochrome P450 2D6

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants

UniProt ID:

P10635

Gene:

CYP2D6

Actions:

inhibitor

References:

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24.
View Article

Cytochrome P450 2E1

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms

UniProt ID:

P05181

Gene:

CYP2E1

Actions:

inhibitor

References:

Cytochrome P450 3A4

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide

UniProt ID:

P08684

Gene:

CYP3A4

Actions:

inhibitor

References:

search → result

Illumina

Contact Us
Correlation Engine APIs
Privacy Policy
Terms of Service
Corporate Home
Site Map

See more about this page

See complete FAQ