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QuickView for vitamin a (compound)
PubChem
| Name: | Vitamin A |
|---|---|
| PubChem Compound ID: | 10565323 |
| Description: | Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. |
| Molecular formula: | C20H30O |
| Molecular weight: | 288.437 g/mol |
DrugBank
Identification
| Name: | Vitamin A |
|---|---|
| Name (isomeric): | DB00162 |
| Drug Type: | small molecule |
| Description: | Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. |
| Synonyms: |
Vitamin A Palmitate; Vitamin A (Feed); trans-Vitamin A alcohol; Vitamin A1; All-trans-Retinyl alcohol; Vitamin A alcohol; trans-Retinol; Retinol; all-trans-Vitamin A1; beta-Retinol.
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| Brand: | Alphasterol, Atars, Atav, Axerol, Vafol, Acon, Vogan-Neu, Agoncal, Thalasphere, Testavol, Aoral, Zineb 80, Nio-A-Let, Mvc Plus, Apexol, A-Mulsal, Retrovitamin A, Anti-Infective vitamin, Avitol, Vogan-nu, Ophthalamin, tROL, Testavol S, M.V.I. Pediatric, Axerophthol, Biosterol, Hi-A-Vita, Vitpex, Sehkraft A, Avita, Vio-A, asterol, M.V.I.-12, Anatola A, Aquasol A, Cylasphere, alin, Chocola A, Ro-a-vit, Aquasol A Parenteral, Avibon, Dofsol, Homagenets Aoral, Afaxin, Alphalin, Solu-A, Lard Factor, Plivit A, Antixerophthalmic vitamin, Zinosan N, Apostavit, Disatabs Tabs, Oleovitamin A, Vogan, Aquasynth, Prepalin, A-Vitan, Zineb, Bentavit A, Veroftal, A-Sol, Homagenets aorl, Anatola, Vaflol, Vi-Dom-A, Dohyfral A, Epiteliol, Del-VI-A, Vi-a, Myvpack, Super A, Vitavel A, A-Vi-Pel, M.V.C. 9+3, Agiolan, Alcovit A, Vi-Alpha |
| Brand name mixture: | Dry Super Vitamin a Plus D - Cap(Vitamin a (Retinol Palmitate) + Vitamin D3), Children's Chewable Multi-Vitamin Complete with Minerals(Biotin + Calcium (Calcium Phosphate (Dibasic)) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron (Iron Citrate) + Nicotinamide + Vitamin a (Vitamin a Palmitate) + Vitam... show more » |
| Category: | Vitamins, Essential Vitamin, Anti-acne Agents, Vitamins (Vitamin A) |
| CAS number: | 68-26-8 |
Pharmacology
| Indication: | For the treatment of vitamin A deficiency. |
|---|---|
| Pharmacology: |
Vitamin A is effective for the treatment of Vitamin A deficiency. Vitamin A refers to a group of fat-soluble substances that are structurally related to and possess the biological activity of the parent substance of the group called all-trans retinol or retinol. Vitamin A plays vital roles in vision, epithelial differentiation, growth, repro...
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| Mechanism of Action: |
Vision:Vitamin A (all-trans retinol) is converted in the retina to the 11-cis-isomer of retinaldehyde or 11-cis-retinal. 11-cis-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-cis-retinal, while attached to opsin in rhodopsin is isomerized to all-tra...
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| Absorption: | Readily absorbed from the normal gastrointestinal tract |
| Protein binding: | <5% of circulating vitamin A is bound to lipoproteins in blood in normal condition, but may be up to 65% when hepatic stores are saturated because of excessive intake. When released from liver, vitamin A is bound to retinol-binding protein (RBP). Most vitamin A circulates in the form of retinol bound to RBP. |
| Biotransformation: | Hepatic. Retinol is conjugated with glucuronic acid; the B-glucuronide undergoes enterohepatic circulation and oxidation to retinol and retinoic acid. Retinoic acid undergoes decarboxylation and conjugation with glucuronic acid. |
| Half Life: | 1.9 hours |
| Toxicity: | Acute toxicity (single ingestion of 7 500 RE or 25 000 IU per kg or more): Signs and symptoms may be delayed for 8 to 24 hours and include: increased intracranial pressure, headache, irritability, drowsiness, dizziness, lethargy, vomiting, diarrhea, bulging of fontanels in infants, diplopia, papilledema. Peeling of skin around mouth may be observed from 1 to several days after ingestion and may spread to the rest of the body. Chronic, excessive ingestion (1 200 RE or 4 000 IU/kg daily for 6 to 15 months) may produce symptoms of pseudotumor cerebri, anorexia, weakness, arthralgias, bone pain, bone demineralization, dry skin, cracked lips, brittle nails, hair loss, splenomegaly, hepatomegaly, hypoplastic anemia, leukopenia, optic neuropathy, and blindness. Increased plasma concentrations of vitamin A occur but do not necessarily correlate with toxicity. |
| Affected organisms: | Humans and other mammals |
Interactions
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