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QuickView for vitamin b 12 (compound)
PubChem
| Name: | Vitamin B 12 |
|---|---|
| PubChem Compound ID: | 10887743 |
| Description: | A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12. |
| Molecular formula: | C63H88CoN14O14P |
| Molecular weight: | 1355.37 g/mol |
DrugBank
Identification
| Name: | Vitamin B 12 |
|---|---|
| Name (isomeric): | DB00115 |
| Drug Type: | small molecule |
| Description: | A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12. |
| Synonyms: |
Vitamin B12 complex; Cyanocob(III)alamin; Vitamine B12; Vitamin B12
|
| Brand: | Rubratope-60 Kit, Cobolin-M, Rubivite, Vibisone, Vitaped, Vi-Twel, Rubramin PC, Cyanocobalamin Co 57 Schilling Test Kit, Crysti-12, Redisol, Dicopac Kit, Vibal, Cernevit-12, Dicopac, Shovite, Ruvite, Bedoz, Cobex, Rubratope-57 Kit, Berocca PN, Cobavite, Vitabee 12, Betalin 12, Berubigen, Crystamine, Anacobin, Depinar, M.V.I. Pediatric, Neuroforte-R, Primabalt, Cyomin, Nascobal, Cyanoject |
| Brand name mixture: | Infuvite Pediatric(), Liver-Stomach Concentrate with Intrinsic Factor(Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid) |
| Category: | Essential Vitamin, Vitamins (Vitamin B Complex), Antianemic Agents |
| CAS number: | 68-19-9 |
Pharmacology
| Indication: | For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency. |
|---|---|
| Pharmacology: | Cyanocobalamin (Vitamin B12) is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It is needed for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia. |
| Mechanism of Action: |
Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed ...
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| Absorption: | Readily absorbed in the lower half of the ileum. |
| Protein binding: | Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin. |
| Biotransformation: | Hepatic |
| Half Life: | Approximately 6 days (400 days in the liver). |
| Toxicity: | Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg |
| Affected organisms: | Humans and other mammals |
Targets
Enzymes
Transporters
