QuickView for wwp1 (gene)

Gene Symbol:

WWP1 Homo sapiens

Full name:

WW domain containing E3 ubiquitin protein ligase 1

Synonyms:

AIP5, Tiul1, hSDRP1, NEDD4-like E3 ubiquitin-protein ligase WWP1, HECT-type E3 ubiquitin transferase WWP1, Nedd-4-like ubiquitin-protein ligase, TGIF-interacting ubiquitin ligase 1, WW domain-containing protein 1, atrophin-1 interacting protein 5

Genomic Location:

Chr 8: 87424110-87549297

Description:

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The...

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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  P53_DECAMER_Q2 ,  MIF1_01 ,  TTCCGTT_MIR191 ,  ACTTTAT_MIR1425P ,  TGACCTY_ERR1_Q2 ,  RGAANNTTC_HSF1_01 ,  GCTCTTG_MIR335 ,  SP1_Q4_01 ,  TGCGCANK_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  ATATGCA_MIR448 ,  CTGCAGY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ER_Q6 ,  TGACCTTG_SF1_Q6 ,  CEBPGAMMA_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7

Cytogenetic Map:

8q21.3

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