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QuickView for xCT (gene)


Gene Symbol:
SLC7A11 Homo sapiens Homo sapiens
Full name:
solute carrier family 7 member 11
Synonyms:
CCBR1, xCT, cystine/glutamate transporter, amino acid transport system xc-, calcium channel blocker resistance protein CCBR1, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Genomic Location:
Chr 4: 139304698-139382953
Description:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated he...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q28.3


Protein Names
Q9UPY5
A8K2U4



GO Molecular Function

organic anion transmembrane transporter activity | anion transmembrane transporter activity | dicarboxylic acid transmembrane transporter activity | neurotransmitter transporter activity | transmembrane transporter activity | organic acid transmembrane transporter activity | L-amino acid transmembrane transporter activity | anion:anion antiporter activity | antiporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | acidic amino acid transmembrane transporter activity | drug transmembrane transporter activity | carboxylic acid transmembrane transporter activity | protein binding | neutral amino acid transmembrane transporter activity | cystine:glutamate antiporter activity | amino acid transmembrane transporter activity | secondary active transmembrane transporter activity | L-glutamate transmembrane transporter activity

GO Biological Process

brain development | cell motility | L-amino acid transport | eye development | organic anion transmembrane transporter activity | establishment of localization | anion transmembrane transporter activity | cell differentiation | nervous system development | response to drug | cellular process | dicarboxylic acid transmembrane transporter activity | localization | neurotransmitter transporter activity | dicarboxylic acid transport | anion transport | hemostasis | tissue development | transmembrane transporter activity | epithelium development | platelet aggregation | head development | response to stimulus | response to stress | organic acid transmembrane transporter activity | L-amino acid transmembrane transporter activity | carboxylic acid transmembrane transport | anion:anion antiporter activity | leukocyte migration | blood coagulation | locomotion | neutral amino acid transport | response to nicotine | system development | multicellular organism development | cell migration | ion transmembrane transport | wound healing | platelet activation | organic substance transport | antiporter activity | active transmembrane transporter activity | response to oxidative stress | organic acid transport | ion transmembrane transporter activity | organic anion transport | acidic amino acid transmembrane transporter activity | response to toxic substance | sensory organ development | drug transmembrane transporter activity | carboxylic acid transmembrane transporter activity | coagulation | amino acid transport | neutral amino acid transmembrane transporter activity | response to wounding | amino acid transmembrane transport | anion transmembrane transport | cystine:glutamate antiporter activity | anatomical structure development | organic acid transmembrane transport | L-alpha-amino acid transmembrane transport | regulation of body fluid levels | L-glutamate transmembrane transport | cell adhesion | animal organ development | amino acid transmembrane transporter activity | secondary active transmembrane transporter activity | cell-cell adhesion | cell activation | drug transport | camera-type eye development | L-glutamate transmembrane transporter activity | transmembrane transport | drug transmembrane transport | carboxylic acid transport | developmental process | neurotransmitter transport | epithelial cell differentiation | central nervous system development | ion transport | immune system process | lens fiber cell differentiation | lens development in camera-type eye | homotypic cell-cell adhesion | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | plasma membrane | membrane-bounded organelle | organelle | cell periphery | rough endoplasmic reticulum | cell surface | cytoskeleton | intracellular | membrane