QuickView for ABAT;jsessionid=AB6B63CC88EE194411D7BC094B8C1CC9;jsessionid=E324FAA341DC9521E0F632AAFFA182FF (gene)
- Gene Symbol:
- Abat
Mus musculus - Full name:
- 4-aminobutyrate aminotransferase
- Synonyms:
- 9630038C02Rik, AI255750, Gabaat, Gabat, Gm9851, I54, Laibat, X61497, 4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, beta-alanine oxoglutarate aminotransferase, gamma-amino-N-butyrate transaminase
- Genomic Location:
- Chr 16: 8513582-8621661
- Description:
-
The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative spl...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cofactor binding | cation binding | 4-aminobutyrate transaminase activity | vitamin binding | coenzyme binding | (S)-3-amino-2-methylpropionate transaminase activity | transaminase activity | pyridoxal phosphate binding | catalytic activity | anion binding | iron-sulfur cluster binding | identical protein binding | ion binding | organic cyclic compound binding | vitamin B6 binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity | drug binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of muscle system process | gamma-aminobutyric acid catabolic process | regulation of localization | negative regulation of gamma-aminobutyric acid secretion | negative regulation of cellular process | response to metal ion | regulation of smooth muscle contraction | response to drug | negative regulation of dopamine secretion | regulation of peptide hormone secretion | positive regulation of protein secretion | response to antibiotic | positive regulation of neurological system process | cellular amino acid catabolic process | cellular process | regulation of catecholamine secretion | organic substance catabolic process | regulation of gamma-aminobutyric acid secretion | modulation of inhibitory postsynaptic potential | exploration behavior | positive regulation of synaptic transmission | regulation of platelet aggregation | negative regulation of amino acid transport | negative regulation of secretion | response to hypoxia | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of neurological system process | negative regulation of neurotransmitter transport | positive regulation of uterine smooth muscle contraction | regulation of platelet activation | negative regulation of wound healing | cellular amino acid metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | negative regulation of response to drug | regulation of peptide secretion | response to stimulus | monocarboxylic acid metabolic process | regulation of insulin secretion | negative regulation of cell adhesion | response to cocaine | carboxylic acid catabolic process | response to stress | cellular amino acid biosynthetic process | regulation of response to drug | reproduction | response to alcohol | regulation of dopamine metabolic process | positive regulation of hormone secretion | negative regulation of transport | regulation of protein transport | blood circulation | regulation of wound healing | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | cellular biosynthetic process | response to iron ion | positive regulation of prolactin secretion | negative regulation of blood pressure | response to ethanol | regulation of catecholamine metabolic process | positive regulation of peptide secretion | regulation of membrane potential | regulation of neurotransmitter levels | response to nitrogen compound | response to nicotine | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of aspartate secretion | regulation of muscle contraction | positive regulation of inhibitory postsynaptic potential | regulation of hormone levels | regulation of hormone secretion | positive regulation of secretion | copulation | regulation of blood pressure | positive regulation of cellular metabolic process | positive regulation of dopamine metabolic process | response to ammonium ion | regulation of blood coagulation | positive regulation of heat generation | regulation of nitrogen compound metabolic process | small molecule metabolic process | behavioral response to cocaine | neurotransmitter metabolic process | regulation of uterine smooth muscle contraction | biosynthetic process | locomotory behavior | negative regulation of ion transport | response to toxic substance | neurotransmitter catabolic process | response to xenobiotic stimulus | negative regulation of response to wounding | negative regulation of cell-cell adhesion | gamma-aminobutyric acid metabolic process | regulation of cellular metabolic process | positive regulation of smooth muscle contraction | negative regulation of cell activation | positive regulation of signal transduction | positive regulation of establishment of protein localization | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of homotypic cell-cell adhesion | negative regulation of catecholamine secretion | regulation of dopamine secretion | carboxylic acid metabolic process | regulation of establishment of protein localization | response to organic substance | regulation of homotypic cell-cell adhesion | positive regulation of insulin secretion | metabolic process | regulation of body fluid levels | regulation of secretion | behavior | positive regulation of muscle contraction | organic substance metabolic process | mating | positive regulation of amino acid transport | positive regulation of ion transport | regulation of cell activation | regulation of protein secretion | response to alkaloid | positive regulation of organic acid transport | positive regulation of protein transport | gamma-aminobutyric acid biosynthetic process | adult behavior | organonitrogen compound catabolic process | neurotransmitter biosynthetic process | regulation of response to wounding | regulation of cell communication | response to organic cyclic compound | organic acid metabolic process | regulation of ion transport | developmental process | positive regulation of anion transport | negative regulation of coagulation | regulation of transport | regulation of cell-cell adhesion | response to organonitrogen compound | regulation of anion transport | negative regulation of blood coagulation | response to anesthetic | positive regulation of metabolic process | cellular metabolic process | negative regulation of platelet activation | negative regulation of platelet aggregation | regulation of protein localization | aging | sexual reproduction | positive regulation of signaling | regulation of signaling | multicellular organismal process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | 4-aminobutyrate transaminase complex | neuron projection | cell | cytoplasm | intracellular organelle | protein-containing complex | cell projection | transferase complex | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular
