QuickView for ABCB11;jsessionid=D453652BDF3A775375D7B8452007F556;jsessionid=D39287344A962BFA1CDC11786759ED1C (gene)

Gene Symbol:

Abcb11 Mus musculus

Full name:

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Synonyms:

ABC16, Bsep, Lith1, PFIC2, PGY4, SPGP, bile salt export pump, ATP-binding cassette, sub-family B, member 11, sister of P-glycoprotein

Genomic Location:

Chr 2: 69076339-69180673

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FXR_IR1_Q6 ,  WGTTNNNNNAAA_UNKNOWN

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