QuickView for ADA;jsessionid=43ABB93FFF8183C403C970D709A97FBB;jsessionid=C952FD5054F553E73A34F09AF1A42BDE;jsessionid=360A729BA0047307142035722923C082;jsessionid=4146A2C7F52B332D71B8719B6628121E (gene)

Gene Symbol:

ADA Homo sapiens

Full name:

adenosine deaminase

Synonyms:

adenosine deaminase, adenosine aminohydrolase

Genomic Location:

Chr 20: 42681577-42713790

Description:

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular im...

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This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HFH4_01 ,  GGGTGGRR_PAX4_03

Cytogenetic Map:

20q13.12

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