QuickView for ADAM10;jsessionid=BD987152E1378B7A1EEEE403DF08AA4A;jsessionid=0F3645A406A5227D0A3FE093CD617C50 (gene)

Gene Symbol:

Adam10 Mus musculus

Full name:

a disintegrin and metallopeptidase domain 10

Synonyms:

1700031C13Rik, MADM, kuz, kuzbanian, disintegrin and metalloproteinase domain-containing protein 10, a disintegrin and metalloprotease domain (ADAM) 10, kuzbanian protein homolog, mammalian disintegrin-metalloprotease

Genomic Location:

Chr 9: 70526986-70626105

Description:

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-boun...

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This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  NMYC_01 ,  CDPCR1_01 ,  CDPCR3HD_01 ,  USF_01 ,  USF_Q6 ,  NRF1_Q6 ,  TFIII_Q6 ,  USF_Q6_01 ,  SP1_Q2_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  TATTATA_MIR374 ,  GTATTAT_MIR3693P ,  TTGCCAA_MIR182 ,  ATGTTTC_MIR494 ,  ATATGCA_MIR448 ,  CAGCTTT_MIR320 ,  MCAATNNNNNGCG_UNKNOWN ,  CTTTGTA_MIR524 ,  AGTCTTA_MIR499 ,  ATGTACA_MIR493 ,  GTTATAT_MIR410 ,  GGTAACC_MIR4095P ,  CAGGTG_E12_Q6 ,  GTGACGY_E4F1_Q6 ,  RYTTCCTG_ETS2_B ,  CACGTG_MYC_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  CGTSACG_PAX3_B ,  GGGCGGR_SP1_Q6 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-499

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