QuickView for ADRB2;jsessionid=D99351D49D1C754AC4BF8202D7EF52BC;jsessionid=A07F771084D792178263504BA9A67512 (gene)
- Gene Symbol:
- Adrb2
Mus musculus - Full name:
- adrenergic receptor, beta 2
- Synonyms:
- Adrb-2, Badm, Gpcr7, beta-2 adrenergic receptor, beta 2-AR, beta-2 adrenoceptor, beta-2 adrenoreceptor
- Genomic Location:
- Chr 18: 62337470-62339613
- Description:
-
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline an...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
receptor-receptor interaction | peptide binding | epinephrine binding | protein phosphatase 2A binding | channel regulator activity | amyloid-beta binding | cation binding | adenylate cyclase binding | transmembrane signaling receptor activity | enzyme binding | beta2-adrenergic receptor activity | protein-containing complex binding | beta-adrenergic receptor activity | G-protein coupled receptor activity | dopamine binding | signaling receptor binding | G-protein coupled amine receptor activity | bradykinin receptor binding | molecular function regulator | adrenergic receptor activity | amide binding | signaling receptor activity | B2 bradykinin receptor binding | identical protein binding | potassium channel regulator activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein phosphatase binding | protein dimerization activity | G-protein coupled receptor binding | norepinephrine binding | drug binding | phosphatase binding | G-protein alpha-subunit binding | glutamate receptor binding | ionotropic glutamate receptor binding
GO Biological Process
positive regulation of heart contraction | response to extracellular stimulus | negative regulation of G-protein coupled receptor protein signaling pathway | respiratory gaseous exchange | multicellular organismal movement | regulation of blood vessel diameter | regulation of muscle system process | regulation of AMPA receptor activity | cellular response to decreased oxygen levels | positive regulation of ATPase activity | positive regulation of macromolecule biosynthetic process | response to nutrient levels | positive regulation of blood circulation | positive regulation of cellular component organization | positive regulation of ion transmembrane transporter activity | regulation of cellular localization | intracellular signal transduction | negative regulation of muscle contraction | positive regulation of skeletal muscle tissue development | positive regulation of apoptotic process | regulation of localization | regulation of the force of heart contraction by chemical signal | positive regulation of striated muscle tissue development | positive regulation of calcium ion import across plasma membrane | regulation of programmed cell death | regulation of sodium ion transport | establishment of localization | regulation of autophagy | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | excitatory postsynaptic potential | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | positive regulation of signaling receptor activity | regulation of smooth muscle contraction | cellular chemical homeostasis | positive regulation of biomineral tissue development | bone remodeling | positive regulation of phosphate metabolic process | positive regulation of cation channel activity | regulation of organelle organization | tissue homeostasis | adaptive thermogenesis | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | channel regulator activity | musculoskeletal movement | localization | cellular homeostasis | positive regulation of protein kinase A signaling | positive regulation of synaptic transmission | tissue remodeling | negative regulation of signaling | chemical synaptic transmission | negative regulation of developmental growth | regulation of platelet aggregation | diet induced thermogenesis | learning | regulation of striated muscle tissue development | positive regulation of protein kinase activity | response to hypoxia | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | brown fat cell differentiation | regulation of bone mineralization | regulation of binding | regulation of neurological system process | anatomical structure homeostasis | beta2-adrenergic receptor activity | regulation of platelet activation | negative regulation of wound healing | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of protein complex disassembly | negative regulation of urine volume | positive regulation of cellular protein metabolic process | bone resorption | cellular response to organonitrogen compound | regulation of urine volume | positive regulation of potassium ion transport | regulation of systemic arterial blood pressure mediated by a chemical signal | calcium ion homeostasis | beta-adrenergic receptor activity | G-protein coupled receptor activity | muscle contraction | associative learning | regulation of vasculature development | response to stimulus | positive regulation of blood pressure | positive regulation of cold-induced thermogenesis | positive regulation of protein metabolic process | negative regulation of cell adhesion | regulation of blood vessel size | response to cold | cellular response to hypoxia | response to stress | regulation of ATPase activity | positive regulation of cation transmembrane transport | adenylate cyclase-activating adrenergic receptor signaling pathway | regulation of skeletal muscle tissue growth | regulation of cell proliferation | multicellular organismal homeostasis | regulation of protein ubiquitination | negative regulation of angiogenesis | regulation of blood circulation | response to peptide | G-protein coupled amine receptor activity | regulation of neurotransmitter receptor activity | positive regulation of autophagosome maturation | response to temperature stimulus | positive regulation of the force of heart contraction by chemical signal | regulation of macroautophagy | blood circulation | G-protein coupled receptor signaling pathway | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of wound healing | modulation of chemical synaptic transmission | regulation of cell adhesion | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | negative regulation of blood pressure | regulation of nucleic acid-templated transcription | regulation of membrane potential | response to nitrogen compound | regulation of calcium ion transport into cytosol | regulation of skeletal muscle tissue development | adrenergic receptor activity | response to oxygen levels | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | respiratory system process | modulation of excitatory postsynaptic potential | positive regulation of calcium ion transmembrane transport | diaphragm contraction | regulation of MAPK cascade | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | positive regulation of muscle organ development | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of sensory perception of pain | regulation of ossification | regulation of protein complex disassembly | wound healing | positive regulation of calcium ion import | regulation of gene expression | regulation of postsynaptic membrane potential | cellular response to stress | nervous system process | cellular response to peptide | regulation of blood pressure | synaptic signaling | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of ion transmembrane transport | regulation of blood coagulation | cellular response to oxygen levels | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of transcription by RNA polymerase II | fat cell differentiation | regulation of the force of heart contraction | negative regulation of binding | positive regulation of hydrolase activity | second-messenger-mediated signaling | synaptic transmission, glutamatergic | cognition | regulation of cellular protein metabolic process | positive regulation of ossification | negative regulation of multicellular organism growth | regulation of calcium ion transmembrane transport | regulation of autophagosome maturation | potassium channel regulator activity | regulation of heart contraction | cation homeostasis | negative regulation of response to wounding | negative regulation of cell-cell adhesion | positive regulation of the force of heart contraction by epinephrine | cellular cation homeostasis | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of cell activation | positive regulation of transporter activity | cyclic-nucleotide-mediated signaling | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | striated muscle contraction | positive regulation of the force of heart contraction by epinephrine-norepinephrine | negative regulation of homotypic cell-cell adhesion | negative adaptation of signaling pathway | regulation of potassium ion transport | positive regulation of molecular function | regulation of signaling receptor activity | activation of adenylate cyclase activity | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of homotypic cell-cell adhesion | positive regulation of lipophagy | cAMP-mediated signaling | regulation of kinase activity | response to wounding | import into cell | negative regulation of ossification | regulation of intracellular signal transduction | involuntary skeletal muscle contraction | cell surface receptor signaling pathway | positive regulation of skeletal muscle tissue growth | vasodilation | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | regulation of tube diameter | regulation of calcium ion import across plasma membrane | chemical homeostasis | endocytosis | behavior | positive regulation of cell death | positive regulation of ion transport | positive regulation of sodium ion transport | regulation of cell activation | positive regulation of programmed cell death | desensitization of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | positive regulation of mini excitatory postsynaptic potential | regulation of ion transmembrane transport | renal system process | positive regulation of autophagy | positive regulation of muscle tissue development | positive regulation of macroautophagy | positive regulation of MAPK cascade | temperature homeostasis | positive regulation of excitatory postsynaptic potential | regulation of protein kinase A signaling | desensitization of G-protein coupled receptor protein signaling pathway by arrestin | regulation of calcium ion import | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | response to amyloid-beta | regulation of transcription, DNA-templated | regulation of protein binding | negative regulation of systemic arterial blood pressure | skeletal muscle contraction | regulation of developmental growth | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | positive regulation of calcium ion transport into cytosol | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | developmental process | norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure | regulation of calcium ion transport | negative regulation of coagulation | regulation of transport | positive regulation of transcription, DNA-templated | adrenergic receptor signaling pathway | regulation of cell-cell adhesion | heat generation | negative regulation of vasculature development | regulation of cation channel activity | positive regulation of nucleic acid-templated transcription | response to dietary excess | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | negative regulation of smooth muscle contraction | regulation of glutamate receptor signaling pathway | negative regulation of blood coagulation | positive regulation of AMPA receptor activity | positive regulation of metabolic process | positive regulation of glutamate receptor signaling pathway | negative regulation of platelet activation | negative regulation of platelet aggregation | cellular response to organic substance | regulation of cell death | positive regulation of blood vessel diameter | regulation of inflammatory response | divalent inorganic cation homeostasis | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of bone mineralization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendritic spine | integral component of membrane | dendrite | intracellular membrane-bounded organelle | sarcolemma | synapse | apical plasma membrane | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | dendritic tree | apical part of cell | protein-containing complex | cell projection | endomembrane system | neuron spine | postsynapse | plasma membrane | membrane raft | vesicle | neuronal cell body membrane | integral component of plasma membrane | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | cell body membrane | axon | plasma membrane raft | intracellular vesicle | intracellular | caveola | membrane | intrinsic component of plasma membrane
