QuickView for AHR;jsessionid=666229D039F1B8F47611904DA3216BD1;jsessionid=DBEFDB16D3EBA72DE0188FE651EA56C8 (gene)

Gene Symbol:

Ahr Mus musculus

Full name:

aryl-hydrocarbon receptor

Synonyms:

Ah, Ahh, Ahre, In, bHLHe76, aryl hydrocarbon receptor, ah receptor, dioxin receptor

Genomic Location:

Chr 12: 36182651-36219661

Description:

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm;...

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The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CREB_02 ,  AREB6_03 ,  TGIF_01 ,  MAZR_01 ,  ATF4_Q2 ,  AP3_Q6 ,  CACBINDINGPROTEIN_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GTGCCTT_MIR506 ,  CATTTCA_MIR203 ,  ATATGCA_MIR448 ,  TGCCTTA_MIR124A ,  ACTTTAT_MIR1425P ,  CAGGTG_E12_Q6 ,  TGACAGNY_MEIS1_01 ,  GGGTGGRR_PAX4_03 ,  RGAGGAARY_PU1_Q6 ,  GGGCGGR_SP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-505

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