QuickView for BMP2;jsessionid=1C27C4B5F520B46C5FFF4D6B10F0AF86;jsessionid=F763C2CA1A3D721DDA819E0C111EAAC3 (gene)
- Gene Symbol:
- Bmp2
Mus musculus - Full name:
- bone morphogenetic protein 2
- Synonyms:
- AI467020, Bmp2a, bone morphogenetic protein 2, bone morphogenetic protein 2A
- Genomic Location:
- Chr 2: 133378935-133388621
- Description:
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
retinol dehydrogenase activity | oxidoreductase activity, acting on CH-OH group of donors | enzyme activator activity | transforming growth factor beta receptor binding | signaling receptor binding | phosphatase activator activity | cytokine receptor binding | receptor serine/threonine kinase binding | molecular function regulator | catalytic activity | protein domain specific binding | co-receptor binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | enzyme regulator activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | BMP receptor binding | SMAD binding | oxidoreductase activity | phosphatase regulator activity
GO Biological Process
regulation of ERK1 and ERK2 cascade | brain development | Notch signaling pathway | SMAD protein signal transduction | positive regulation of macromolecule biosynthetic process | retinol dehydrogenase activity | positive regulation of locomotion | regulation of dephosphorylation | oxidoreductase activity, acting on CH-OH group of donors | regulation of neurogenesis | muscle tissue development | enzyme activator activity | positive regulation of apoptotic process | regulation of cell development | regulation of localization | morphogenesis of an epithelium | cell proliferation involved in kidney development | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | regulation of osteoblast proliferation | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | regulation of phosphatase activity | negative regulation of RNA biosynthetic process | bone development | cell differentiation | positive regulation of epithelial cell proliferation | bone mineralization | defense response | nervous system development | epithelial to mesenchymal transition | positive regulation of biomineral tissue development | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | mesenchyme development | telencephalon regionalization | pattern specification process | positive regulation of dephosphorylation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | positive regulation of cartilage development | regulation of cell motility | regulation of steroid hormone biosynthetic process | epithelial tube morphogenesis | odontogenesis | heart morphogenesis | negative regulation of signaling | positive regulation of epithelial to mesenchymal transition | positive regulation of pathway-restricted SMAD protein phosphorylation | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | regulation of striated muscle tissue development | positive regulation of protein kinase activity | glandular epithelial cell differentiation | negative regulation of lipid biosynthetic process | branching involved in ureteric bud morphogenesis | response to hypoxia | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | diencephalon development | pathway-restricted SMAD protein phosphorylation | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of osteoblast differentiation | negative regulation of cardiocyte differentiation | regulation of apoptotic process | regulation of metabolic process | negative regulation of aldosterone biosynthetic process | pituitary gland development | positive regulation of stress-activated MAPK cascade | regulation of odontogenesis of dentin-containing tooth | positive regulation of cellular protein metabolic process | epithelium development | response to transforming growth factor beta | urogenital system development | positive regulation of protein binding | nephron tubule morphogenesis | head development | negative regulation of cardiac muscle tissue development | positive regulation of stress-activated protein kinase signaling cascade | muscle organ morphogenesis | negative regulation of insulin-like growth factor receptor signaling pathway | response to stimulus | positive regulation of protein metabolic process | negative regulation of striated muscle cell differentiation | negative regulation of cell adhesion | phosphatase activator activity | response to stress | regulation of cell proliferation | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | proteoglycan metabolic process | negative regulation of glucocorticoid biosynthetic process | forebrain regionalization | protein destabilization | positive regulation of phosphatase activity | atrioventricular valve morphogenesis | positive regulation of gliogenesis | cellular response to organic cyclic compound | negative regulation of muscle tissue development | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of odontogenesis | pericardium development | cartilage development | regulation of cell adhesion | regulation of steroid biosynthetic process | kidney development | embryo development | macromolecule modification | adenohypophysis development | cell-cell signaling | regulation of steroid metabolic process | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | activation of protein kinase activity | negative regulation of Wnt signaling pathway involved in heart development | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to BMP | endocardial cushion development | system development | chondrocyte differentiation | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | ureteric bud development | regulation of protein stability | regulation of cartilage development | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | neuroepithelial cell differentiation | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | kidney morphogenesis | regulation of hormone levels | regulation of ossification | cardiac epithelial to mesenchymal transition | telencephalon development | regulation of neuron differentiation | regulation of gene expression | kidney epithelium development | endocardial cushion morphogenesis | negative regulation of cardiac muscle cell differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of aldosterone metabolic process | regulation of pri-miRNA transcription by RNA polymerase II | regulation of ketone biosynthetic process | positive regulation of p38MAPK cascade | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | cardiocyte differentiation | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of cell migration | cell proliferation | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of ossification | mesenchyme morphogenesis | phosphorylation | mesonephric epithelium development | positive regulation of pri-miRNA transcription by RNA polymerase II | positive regulation of odontogenesis | BMP signaling pathway involved in heart induction | endocrine system development | protein phosphorylation | negative regulation of calcium-independent cell-cell adhesion | mesonephros development | phosphate-containing compound metabolic process | sensory organ development | mesenchymal cell proliferation involved in ureteric bud development | negative regulation of cell-cell adhesion | chordate embryonic development | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | corticotropin hormone secreting cell differentiation | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | renal tubule development | odontogenesis of dentin-containing tooth | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | positive regulation of osteoblast proliferation | negative regulation of striated muscle tissue development | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | neuroendocrine cell differentiation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | regulation of lipid biosynthetic process | striated muscle cell differentiation | positive regulation of Wnt signaling pathway by BMP signaling pathway | ossification involved in bone maturation | nephron development | positive regulation of molecular function | positive regulation of osteoblast differentiation | cellular response to transforming growth factor beta stimulus | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | ureteric bud morphogenesis | heart valve development | protein metabolic process | regulation of glucocorticoid biosynthetic process | regionalization | positive regulation of protein modification process | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | regulation of insulin-like growth factor receptor signaling pathway | branching morphogenesis of an epithelial tube | regulation of kinase activity | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | growth factor activity | negative regulation of lipid metabolic process | metabolic process | positive regulation of cell development | cell fate commitment | mesenchymal cell differentiation | negative regulation of steroid hormone biosynthetic process | regulation of RNA biosynthetic process | developmental maturation | oxidation-reduction process | negative regulation of transcription, DNA-templated | ear development | positive regulation of glial cell differentiation | positive regulation of cell death | receptor ligand activity | mesenchymal cell proliferation | cytokine activity | heart valve morphogenesis | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | regulation of endothelial cell proliferation | forebrain development | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of heart morphogenesis | regulation of Wnt signaling pathway | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | biomineral tissue development | positive regulation of astrocyte differentiation | positive regulation of binding | atrioventricular valve development | positive regulation of MAPK cascade | morphogenesis of a branching epithelium | transforming growth factor beta receptor signaling pathway | negative regulation of cell cycle | regulation of animal organ formation | bone maturation | cardiac muscle cell differentiation | negative regulation of hormone biosynthetic process | BMP signaling pathway | regulation of glial cell differentiation | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of gliogenesis | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | thyroid-stimulating hormone-secreting cell differentiation | response to organic cyclic compound | cell development | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | morphogenesis of a branching structure | anatomical structure morphogenesis | positive regulation of fat cell differentiation | positive regulation of MAP kinase activity | regulation of cortisol biosynthetic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | negative regulation of cortisol biosynthetic process | developmental process | regulation of muscle cell differentiation | negative regulation of steroid metabolic process | cellular protein modification process | embryonic heart tube anterior/posterior pattern specification | negative regulation of transcription by RNA polymerase II | tube development | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | central nervous system development | negative regulation of muscle cell differentiation | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | ossification | positive regulation of neuron differentiation | cellular response to BMP stimulus | organ induction | osteoblast differentiation | skeletal system development | positive regulation of Wnt signaling pathway | cellular metabolic process | regulation of glucocorticoid metabolic process | cellular response to organic substance | regulation of astrocyte differentiation | regulation of cell death | positive regulation of cell motility | oxidoreductase activity | bone mineralization involved in bone maturation | developmental induction | circulatory system development | glycoprotein metabolic process | nephron tubule development | negative regulation of cell differentiation | negative regulation of steroid biosynthetic process | positive regulation of bone mineralization | muscle organ development | phosphatase regulator activity | positive regulation of signaling | signal transduction | regulation of signaling | regulation of p38MAPK cascade | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | regulation of hormone biosynthetic process | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | BMP receptor complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | plasma membrane | vesicle | integral component of plasma membrane | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | cell surface | intracellular | membrane | intrinsic component of plasma membrane
