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QuickView for BRAF;jsessionid=2547D466A978ABBB1602416142B7EAE5;jsessionid=DB8C3B61C62A76DDE4B68BB701ECDB69 (gene)


Gene Symbol:
Braf Rattus norvegicus Rattus norvegicus
Full name:
B-Raf proto-oncogene, serine/threonine kinase
Synonyms:
serine/threonine-protein kinase B-raf, v-raf murine sarcoma viral oncogene homolog B, v-raf murine sarcoma viral oncogene homolog B1
Genomic Location:
Chr 4: 67115294-67243221
Description:
human homolog is a serine/threonine kinase; mutation of gene is associated with human cancers
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

kinase binding | GTPase binding | cation binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | purine nucleotide binding | mitogen-activated protein kinase kinase binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | small GTPase binding | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of immune response | regulation of ERK1 and ERK2 cascade | regulation of supramolecular fiber organization | response to radiation | negative regulation of intracellular transport | CD4-positive, alpha-beta T cell differentiation | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | CD4-positive, alpha-beta T cell activation | immune response-regulating signaling pathway | regulation of cellular localization | intracellular signal transduction | positive regulation of axon regeneration | regulation of cell development | regulation of localization | somatic stem cell population maintenance | regulation of programmed cell death | T cell lineage commitment | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | response to metal ion | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | nervous system development | response to drug | positive regulation of axonogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | regulation of fibroblast migration | generation of neurons | regulation of neuron death | response to organophosphorus | cellular process | lymphocyte differentiation | disaccharide metabolic process | regulation of cell motility | localization | positive regulation of synaptic transmission | negative regulation of signaling | visual learning | positive regulation of peptidyl-serine phosphorylation | immune system development | learning | stem cell population maintenance | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | regulation of neuron projection development | response to inorganic substance | response to peptide hormone | regulation of cell differentiation | negative regulation of neurotransmitter transport | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | trehalose metabolism in response to stress | regulation of metabolic process | head morphogenesis | response to nerve growth factor | positive regulation of cellular protein metabolic process | cellular component organization | MAPK cascade | cellular response to metal ion | T cell activation | head development | thyroid gland development | associative learning | response to stimulus | negative regulation of epithelial cell apoptotic process | thymus development | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | regulation of cell proliferation | positive regulation of actin filament bundle assembly | response to peptide | hematopoietic progenitor cell differentiation | protein serine/threonine kinase activity | cellular response to inorganic substance | cellular localization | regulation of neuron projection regeneration | immune response-activating signal transduction | negative regulation of transport | positive regulation of protein serine/threonine kinase activity | hemopoiesis | cellular component assembly | protein modification process | modulation of chemical synaptic transmission | regulation of cell adhesion | macromolecule modification | activation of protein kinase activity | regulation of intracellular transport | regulation of lymphocyte differentiation | positive regulation of stress fiber assembly | leukocyte differentiation | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of neuron apoptotic process | response to light stimulus | system development | positive regulation of response to wounding | nitrogen compound metabolic process | negative regulation of synaptic vesicle exocytosis | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | positive regulation of neuron projection development | regulation of actin cytoskeleton organization | multicellular organism development | regulation of synaptic vesicle exocytosis | regulation of MAPK cascade | phosphorus metabolic process | response to purine-containing compound | regulation of actin filament organization | learning or memory | regulation of axonogenesis | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of actomyosin structure organization | cellular response to nerve growth factor stimulus | regulation of phosphorylation | positive regulation of neuron projection regeneration | regulation of T cell activation | regulation of neuron differentiation | regulation of gene expression | protein localization to membrane | cellular response to stress | nervous system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | MAP kinase kinase kinase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | cellular carbohydrate metabolic process | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | regulation of cellular component movement | alpha-beta T cell differentiation | regulation of endothelial cell apoptotic process | negative regulation of fibroblast migration | positive regulation of cell differentiation | cognition | positive regulation of glucose transmembrane transport | negative regulation of neurotransmitter secretion | regulation of cellular protein metabolic process | phosphorylation | carbohydrate metabolic process | regulation of synaptic vesicle transport | endocrine system development | regulation of epithelial cell apoptotic process | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | activation of MAPKK activity | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | trehalose metabolic process | oligosaccharide metabolic process | lymphocyte activation | positive regulation of molecular function | negative regulation of exocytosis | establishment of protein localization to membrane | T cell differentiation | protein-containing complex assembly | activation of immune response | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | cellular response to calcium ion | T cell selection | response to organic substance | gland development | visual behavior | regulation of hemopoiesis | regulation of kinase activity | myeloid progenitor cell differentiation | regulation of intracellular signal transduction | regulation of exocytosis | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | cell fate commitment | positive regulation of supramolecular fiber organization | negative regulation of programmed cell death | cellular protein localization | positive T cell selection | regulation of vesicle-mediated transport | regulation of secretion | behavior | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | maintenance of cell number | regulation of glucose transmembrane transport | animal organ development | positive regulation of cell-substrate adhesion | regulation of cell activation | negative regulation of cellular component movement | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | alpha-beta T cell activation | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | establishment of protein localization | regulation of regulated secretory pathway | response to cAMP | cell activation | positive regulation of MAPK cascade | regulation of axon regeneration | regulation of peptidyl-serine phosphorylation | regulation of stress fiber assembly | regulation of response to wounding | regulation of cell communication | signaling | response to organic cyclic compound | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | protein heterooligomerization | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of MAP kinase activity | regulation of actin filament bundle assembly | regulation of nervous system development | regulation of developmental process | negative regulation of calcium ion-dependent exocytosis | kinase activity | developmental process | cellular protein modification process | regulation of transport | response to organonitrogen compound | negative regulation of synaptic transmission | regulation of calcium ion-dependent exocytosis | response to calcium ion | positive regulation of metabolic process | regulation of actin filament-based process | regulation of synaptic plasticity | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular metabolic process | long-term synaptic potentiation | body morphogenesis | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | regulation of substrate adhesion-dependent cell spreading | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | negative regulation of locomotion | positive regulation of substrate adhesion-dependent cell spreading | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | positive regulation of gene expression | regulation of neurotransmitter secretion | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | face development | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | neuron projection | cell body | cell | cytoplasm | intracellular organelle | cell projection | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane