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QuickView for BRCA1;jsessionid=69052E120845B0F75D3DDDC3AD8FCC73;jsessionid=BA6A86E8C14D45AF1C9510292F1B9F67 (gene)


Gene Symbol:
Brca1 Rattus norvegicus Rattus norvegicus
Full name:
BRCA1, DNA repair associated
Synonyms:
breast cancer type 1 susceptibility protein homolog, RING-type E3 ubiquitin transferase BRCA1, breast cancer 1, early onset
Genomic Location:
Chr 10: 90513630-90572676
Description:
involved in the DNA damage response and DNA repair
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_012514
XM_008768092
Protein Names
P97951
O54952
G3V8S5



GO Molecular Function

transcription regulatory region DNA binding | RNA polymerase binding | cation binding | enzyme binding | nucleic acid binding | catalytic activity | chromatin binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | DNA binding | damaged DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | zinc ion binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding | RNA binding

GO Biological Process

RNA metabolic process | response to extracellular stimulus | brain development | double-strand break repair | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | response to cytokine | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of histone H3-K9 methylation | regulation of programmed cell death | cellular response to indole-3-methanol | regulation of DNA methylation | response to hormone | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | microtubule cytoskeleton organization | regulation of protein import | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | regulation of organelle organization | regulation of DNA repair | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | negative regulation of signaling | response to estradiol | positive regulation of histone H4-K16 acetylation | regulation of histone H3-K9 methylation | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | postreplication repair | microtubule organizing center organization | dosage compensation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of histone H3-K9 acetylation | intrinsic apoptotic signaling pathway | negative regulation of histone methylation | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | regulation of histone H4-K16 acetylation | positive regulation of histone H4 acetylation | head development | regulation of histone methylation | regulation of vasculature development | response to stimulus | regulation of cellular protein localization | monocarboxylic acid metabolic process | regulation of mitotic cell cycle phase transition | regulation of fatty acid biosynthetic process | genetic imprinting | chromosome segregation | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | regulation of cell cycle phase transition | programmed cell death | positive regulation of vascular endothelial growth factor production | response to alcohol | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | cellular biosynthetic process | embryo development | DNA recombination | macromolecule modification | protein K6-linked ubiquitination | regulation of intracellular transport | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | double-strand break repair via homologous recombination | multicellular organism development | negative regulation of cell cycle G2/M phase transition | cellular response to DNA damage stimulus | lipid metabolic process | regulation of intracellular estrogen receptor signaling pathway | positive regulation of chromosome organization | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of histone H4-K20 methylation | negative regulation of histone H3-K9 methylation | cellular response to stress | response to lipid | cell cycle | regulation of histone H4 acetylation | positive regulation of intracellular protein transport | regulation of protein import into nucleus, translocation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | small molecule metabolic process | dosage compensation by inactivation of X chromosome | regulation of transcription by RNA polymerase II | response to nutrient | regulation of fatty acid metabolic process | negative regulation of extrinsic apoptotic signaling pathway | negative regulation of intracellular steroid hormone receptor signaling pathway | fatty acid biosynthetic process | cellular response to cytokine stimulus | positive regulation of histone H3-K9 acetylation | positive regulation of protein localization to nucleus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | lipid biosynthetic process | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | cellular response to drug | response to estrogen | chordate embryonic development | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | regulation of histone H3-K4 methylation | positive regulation of establishment of protein localization | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of protein acetylation | positive regulation of transport | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | regulation of lipid biosynthetic process | negative regulation of intracellular estrogen receptor signaling pathway | apoptotic signaling pathway | regulation of mitotic cell cycle | carboxylic acid metabolic process | regulation of nucleocytoplasmic transport | protein polyubiquitination | positive regulation of cell cycle arrest | mitotic G2/M transition checkpoint | regulation of gene expression by genetic imprinting | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | protein ubiquitination | regulation of protein import into nucleus | centrosome cycle | DNA metabolic process | response to antineoplastic agent | positive regulation of peptidyl-lysine acetylation | protein autoubiquitination | anatomical structure development | mitotic cell cycle | negative regulation of lipid metabolic process | metabolic process | ubiquitin-protein transferase activity | negative regulation of histone H3-K4 methylation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | negative regulation of histone acetylation | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | signal transduction involved in G2 DNA damage checkpoint | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | protein modification by small protein conjugation or removal | cytoskeleton organization | regulation of chromosome organization | fatty acid metabolic process | transcription, DNA-templated | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of cell cycle | negative regulation of protein metabolic process | positive regulation of protein import into nucleus, translocation | regulation of cell communication | negative regulation of chromosome organization | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | response to indole-3-methanol | organic acid metabolic process | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | positive regulation of protein import into nucleus | signal transduction involved in DNA damage checkpoint | regulation of cellular ketone metabolic process | regulation of developmental process | positive regulation of DNA metabolic process | recombinational repair | developmental process | organelle organization | positive regulation of protein import | positive regulation of cell cycle process | cellular protein modification process | regulation of histone acetylation | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of vascular endothelial growth factor production | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of histone methylation | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | negative regulation of cell death | negative regulation of fatty acid biosynthetic process | positive regulation of nucleocytoplasmic transport | positive regulation of angiogenesis | positive regulation of protein ubiquitination | regulation of cellular component organization | response to ionizing radiation | negative regulation of reactive oxygen species metabolic process | negative regulation of fatty acid metabolic process | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

condensed nuclear chromosome | mitochondrial matrix | BRCA1-BARD1 complex | lateral element | chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear ubiquitin ligase complex | cell | nuclear lumen | synaptonemal complex | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | BRCA1-A complex | plasma membrane | nuclear chromosome | ribonucleoprotein complex | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | intracellular | membrane | condensed chromosome