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QuickView for BRCA2;jsessionid=4743BD6FAA6C4B3AEABAF5593E96A0A2;jsessionid=1672894CCF2B2FE58BB98419D74AF85C;jsessionid=F59ECC276F095A2301AAE204C4228B94;jsessionid=BEFA3BD6B03B5E72B36F0497944B0DE6 (gene)


Gene Symbol:
Brca2 Rattus norvegicus Rattus norvegicus
Full name:
BRCA2, DNA repair associated
Synonyms:
breast cancer type 2 susceptibility protein homolog, breast cancer 2, early onset, breast cancer 2, mutation 1, University of Wisconsin-Madison, breast cancer susceptibility protein 2, fanconi anemia group D1 protein homolog
Genomic Location:
Chr 12: 4282952-4323693
Description:
tumor suppression gene; involved in repair of double-strand DNA breaks (DSBs) by homologous recombination
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:





GO Molecular Function

N-acetyltransferase activity | transferase activity, transferring acyl groups other than amino-acyl groups | N-acyltransferase activity | enzyme binding | nucleic acid binding | single-stranded DNA binding | catalytic activity | cytoskeletal protein binding | transferase activity, transferring acyl groups | histone acetyltransferase activity | DNA binding | identical protein binding | organic cyclic compound binding | peptide N-acetyltransferase activity | H4 histone acetyltransferase activity | protein binding | transferase activity | peptide-lysine-N-acetyltransferase activity | tubulin binding | H3 histone acetyltransferase activity | gamma-tubulin binding | protease binding | acetyltransferase activity | heterocyclic compound binding | protein C-terminus binding

GO Biological Process

mitotic cytokinesis | response to extracellular stimulus | brain development | double-strand break repair | meiotic metaphase plate congression | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | response to nutrient levels | developmental process involved in reproduction | intracellular signal transduction | gonad development | female gonad development | peptidyl-amino acid modification | response to X-ray | regulation of meiotic cell cycle | establishment of localization | response to hormone | mitotic recombination-dependent replication fork processing | negative regulation of cellular process | meiotic recombination checkpoint | histone modification | microtubule cytoskeleton organization | cell differentiation | male gamete generation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | multicellular organism growth | male meiotic nuclear division | histone H3 acetylation | meiotic DNA repair synthesis | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | negative regulation of meiotic cell cycle | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | DNA-dependent DNA replication maintenance of fidelity | establishment of organelle localization | localization | chromatin organization | cell maturation | mitotic DNA replication maintenance of fidelity | developmental growth | reproductive system development | response to estradiol | cell cycle DNA replication | cytoskeleton-dependent cytokinesis | immune system development | multicellular organismal reproductive process | macromolecule localization | microtubule organizing center organization | inner cell mass cell proliferation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | mitotic DNA replication | establishment of localization in cell | negative regulation of cellular metabolic process | gamete generation | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | organelle localization | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | meiotic DNA repair synthesis involved in reciprocal meiotic recombination | establishment of chromosome localization | regulation of cell division | development of primary sexual characteristics | response to UV | head development | negative regulation of DNA replication | histone H4 acetylation | male meiosis I | response to stimulus | female gamete generation | chromosome segregation | response to stress | germ cell development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of mammary gland epithelial cell proliferation | programmed cell death | development of primary female sexual characteristics | reproduction | cellular localization | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | telomere organization | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | cellular biosynthetic process | embryo development | DNA recombination | macromolecule modification | meiotic chromosome segregation | DNA repair | regulation of nucleic acid-templated transcription | apoptotic process | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | DNA damage response, signal transduction by p53 class mediator | replication fork processing | double-strand break repair via homologous recombination | multicellular organism development | protein acetylation | mammary gland development | cellular response to DNA damage stimulus | negative regulation of meiotic nuclear division | oocyte differentiation | histone acetyltransferase activity | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | DNA biosynthetic process | cellular response to stress | response to lipid | cell cycle | positive regulation of cellular metabolic process | establishment of protein localization to chromosome | regulation of nitrogen compound metabolic process | response to nutrient | oogenesis | protein localization to organelle | negative regulation of mammary gland epithelial cell proliferation | DNA synthesis involved in double-strand break repair via homologous recombination | cell proliferation | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | cell division | metaphase plate congression | aromatic compound biosynthetic process | cytokinesis | meiotic cell cycle checkpoint | regulation of DNA-dependent DNA replication | response to gamma radiation | nuclear chromosome segregation | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | meiotic metaphase I plate congression | homeostatic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | H4 histone acetyltransferase activity | apoptotic signaling pathway | cell aging | regulation of mitotic cell cycle | multicellular organism reproduction | homologous chromosome segregation | negative regulation of epithelial cell proliferation | protein metabolic process | centrosome duplication | response to organic substance | gland development | regulation of meiotic nuclear division | negative regulation of DNA-dependent DNA replication | centrosome cycle | protein localization to chromosome, telomeric region | DNA metabolic process | reciprocal meiotic recombination | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | nuclear division | metabolic process | nucleotide-excision repair | homologous chromosome orientation involved in meiotic metaphase I plate congression | regulation of RNA biosynthetic process | developmental maturation | cellular protein localization | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | animal organ development | mitotic recombination | cytoskeleton organization | replication fork protection | telomere maintenance via recombination | intrinsic apoptotic signaling pathway by p53 class mediator | establishment of protein localization | blastocyst development | meiosis I | oocyte development | attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation | attachment of spindle microtubules to kinetochore | negative regulation of cell cycle | meiotic cell cycle | establishment of protein localization to telomere | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | response to UV-C | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | cell development | internal protein amino acid acetylation | protein localization | regulation of epithelial cell proliferation | H3 histone acetyltransferase activity | cellular protein metabolic process | cellular macromolecule localization | cellular macromolecule biosynthetic process | homologous recombination | reproductive structure development | nuclear DNA replication | regulation of developmental process | recombinational repair | developmental process | organelle organization | spermatogenesis | blastocyst growth | cellular protein modification process | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | oocyte maturation | heterocycle metabolic process | central nervous system development | in utero embryonic development | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | sex differentiation | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | aging | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | protein localization to chromosome | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

condensed nuclear chromosome | secretory granule | lateral element | chromosome | intracellular membrane-bounded organelle | microtubule organizing center | cytoplasmic vesicle | cell | nuclear lumen | synaptonemal complex | cytoplasm | BRCA2-MAGE-D1 complex | intracellular organelle | centrosome | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | nuclear chromosome | vesicle | microtubule cytoskeleton | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular vesicle | cytoskeleton | nuclear chromosome, telomeric region | intracellular | condensed chromosome