QuickView for BRCA2;jsessionid=4743BD6FAA6C4B3AEABAF5593E96A0A2;jsessionid=B49EE29900787751E06F4577F55625F2;jsessionid=2E0206752E9BC0DD1E96183001538C31;jsessionid=673C02E1C0C4CCC24A2365974E7E35A2 (gene)

Gene Symbol:

BRCA2 Homo sapiens

Full name:

BRCA2, DNA repair associated

Synonyms:

BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer type 2 susceptibility protein, BRCA1/BRCA2-containing complex, subunit 2, Fanconi anemia group D1 protein, breast and ovarian cancer susceptibility gene, early onset, breast and ovarian cancer susceptibility protein 2, breast cancer 2 tumor suppressor, breast cancer 2, early onset, mutant BRCA2, truncated breast cancer 2

Genomic Location:

Chr 13: 31787617-31871809

Description:

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC moti...

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Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TATAAA_TATA_01 ,  GTGACGY_E4F1_Q6 ,  GGATTA_PITX2_Q2 ,  PITX2_Q2

Cytogenetic Map:

13q13.1

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