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QuickView for CD28;jsessionid=FE733E395F2F8E4AA63771BB47C5C26F;jsessionid=EFAFBC1B70A92EA46AA95ECAC6144065 (gene)


Gene Symbol:
Cd28 Rattus norvegicus Rattus norvegicus
Full name:
Cd28 molecule
Synonyms:
CD28RNA, T-cell-specific surface glycoprotein CD28, CD28 antigen
Genomic Location:
Chr 9: 59342273-59367743
Description:
costimulatory molecule involved in induction of T cell proliferation and initiation of the Th2 response; may be important in maintanence of basal IgE production; binds to B7-1 or B7-2 on antigen presenting cells (APCs)
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_013121
XM_008767078
XM_008767079
Protein Names
P31042



GO Molecular Function

kinase binding | protein kinase binding | coreceptor activity | enzyme binding | signaling adaptor activity | protein binding, bridging | signaling receptor activity | identical protein binding | molecular adaptor activity | protein binding | protein homodimerization activity | protein dimerization activity | SH3/SH2 adaptor activity | protease binding

GO Biological Process

positive regulation of immune response | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of B cell activation | immune response-regulating signaling pathway | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | lymphocyte costimulation | positive regulation of DNA recombination | positive regulation of cell adhesion | regulation of organelle organization | negative T cell selection | regulation of isotype switching to IgG isotypes | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | regulation of cytokine biosynthetic process | positive regulation of immune effector process | positive regulation of adaptive immune response | regulation of mitotic nuclear division | immune system development | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | negative thymic T cell selection | positive regulation of interleukin-4 production | T cell activation | response to stimulus | regulation of DNA recombination | regulation of regulatory T cell differentiation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | positive regulation of immunoglobulin production | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | regulation of cell adhesion | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | leukocyte differentiation | apoptotic process | regulation of interleukin-2 biosynthetic process | signaling adaptor activity | positive regulation of mononuclear cell proliferation | system development | regulation of interleukin-4 production | regulation of signal transduction | positive regulation of organelle organization | multicellular organism development | positive regulation of inflammatory response | positive regulation of protein kinase B signaling | regulation of T cell activation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | positive regulation of interleukin-2 biosynthetic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of immunoglobulin mediated immune response | positive regulation of T cell proliferation | positive regulation of isotype switching | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of RNA metabolic process | positive regulation of B cell activation | apoptotic signaling pathway | regulation of mitotic cell cycle | lymphocyte activation | T cell differentiation | activation of immune response | T cell selection | T cell differentiation in thymus | regulation of hemopoiesis | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | regulation of isotype switching | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | positive regulation of inflammatory response to antigenic stimulus | immune response | thymic T cell selection | cell death | negative regulation of gene expression | animal organ development | regulation of cell activation | regulatory T cell differentiation | SH3/SH2 adaptor activity | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | cell activation | T cell costimulation | regulation of cell communication | positive regulation of interleukin-10 production | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | regulation of T cell proliferation | regulation of cytokine production | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | positive regulation of alpha-beta T cell activation | positive regulation of cell cycle process | positive regulation of interleukin-2 production | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of isotype switching to IgG isotypes | positive regulation of metabolic process | immune system process | hematopoietic or lymphoid organ development | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | multicellular organismal process

GO Cellular Component

integral component of membrane | immunological synapse | cell | intrinsic component of membrane | external side of plasma membrane | membrane microdomain | protein-containing complex | plasma membrane | membrane raft | cell periphery | protein complex involved in cell adhesion | cell surface | membrane