QuickView for CDK2;jsessionid=FC0FB3AEC80DA2F002DCF51A6517AAC8;jsessionid=C043963185302888A903CC87AE876FF5 (gene)
- Gene Symbol:
- CDC28
Saccharomyces cerevisiae - Full name:
- Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
- Synonyms:
- CDC28, CDK1, HSL5, SRM5, YBR160W
- Genomic Location:
- Chr II: 560072-560968
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
RNA polymerase II complex binding | cyclin binding | RNA polymerase binding | enzyme binding | ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | RNA polymerase core enzyme binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | histone binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | regulation of telomere maintenance via telomerase | double-strand break repair | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | microtubule cytoskeleton organization involved in mitosis | RNA processing | positive regulation of cellular component organization | regulation of cellular localization | regulation of localization | regulation of carbohydrate metabolic process | nucleosome organization | positive regulation of lipid catabolic process | peptidyl-amino acid modification | regulation of meiotic cell cycle | establishment of localization | regulation of nuclear cell cycle DNA replication | negative regulation of cellular process | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | attachment of mitotic spindle microtubules to kinetochore | positive regulation of glycogen catabolic process | regulation of DNA replication | regulation of organelle organization | protein localization to spindle microtubule | negative regulation of DNA metabolic process | negative regulation of meiotic cell cycle | protein localization to microtubule | regulation of DNA repair | microtubule-based process | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | synapsis | organic substance catabolic process | establishment of organelle localization | localization | 7-methylguanosine mRNA capping | chromatin organization | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of chromosome segregation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | spindle assembly | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of cellular process | regulation of metabolic process | positive regulation of nuclear cell cycle DNA replication | catabolic process | organelle localization | negative regulation of DNA repair | organic cyclic compound metabolic process | mitotic sister chromatid biorientation | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | establishment of chromosome localization | regulation of cell division | regulation of glycogen catabolic process | response to stimulus | peptidyl-threonine phosphorylation | cyclin-dependent protein kinase activity | regulation of DNA recombination | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | chromosome segregation | mitotic spindle organization | sister chromatid biorientation | response to stress | regulation of cell proliferation | regulation of double-strand break repair | protein localization to nucleus | regulation of cell cycle phase transition | protein serine/threonine kinase activity | reproduction | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | protein localization to nuclear periphery | double-strand break repair via nonhomologous end joining | cell cycle G1/S phase transition | regulation of DNA binding | positive regulation of meiotic cell cycle | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | mRNA metabolic process | regulation of triglyceride metabolic process | macromolecule modification | meiotic chromosome segregation | DNA repair | regulation of budding cell apical bud growth | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | organelle assembly | regulation of cell cycle G2/M phase transition | positive regulation of mitotic spindle pole body separation | nitrogen compound metabolic process | reproductive process | positive regulation of organelle organization | positive regulation of DNA replication | sister chromatid segregation | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of telomere maintenance | post-Golgi vesicle-mediated transport | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | cellular response to stress | DNA double-strand break processing | cell cycle | protein catabolic process | regulation of trehalose metabolic process | regulation of DNA replication origin binding | regulation of spindle assembly | positive regulation of cellular metabolic process | mitotic metaphase plate congression | synaptonemal complex assembly | regulation of nitrogen compound metabolic process | negative regulation of DNA binding | vesicle-mediated transport | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of binding | negative regulation of double-strand break repair | phosphorylation of RNA polymerase II C-terminal domain | negative regulation of double-strand break repair via nonhomologous end joining | cell division | metaphase plate congression | synaptonemal complex organization | phosphorylation | regulation of DNA-dependent DNA replication | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | regulation of telomere maintenance via telomere lengthening | regulation of cellular metabolic process | regulation of lipid catabolic process | positive regulation of cytoskeleton organization | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | Golgi vesicle transport | regulation of RNA metabolic process | regulation of double-strand break repair via nonhomologous end joining | regulation of double-strand break repair via homologous recombination | regulation of mitotic cell cycle | regulation of microtubule-based process | regulation of sister chromatid cohesion | positive regulation of triglyceride metabolic process | homologous chromosome segregation | protein metabolic process | regulation of growth | positive regulation of trehalose catabolic process | DNA metabolic process | cyclin-dependent protein serine/threonine kinase activity | cellular macromolecule catabolic process | regulation of sister chromatid segregation | mitotic cell cycle | regulation of glucose metabolic process | nuclear division | metabolic process | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of mitotic cell cycle | cellular protein localization | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | protein kinase activity | positive regulation of DNA-dependent DNA replication | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | negative regulation of sister chromatid cohesion | cytoskeleton organization | regulation of chromosome organization | chromosome organization involved in meiotic cell cycle | mitotic nuclear division | negative regulation of DNA replication origin binding | meiosis I | attachment of spindle microtubules to kinetochore | negative regulation of cell cycle | regulation of protein localization to chromatin | positive regulation of carbohydrate metabolic process | organonitrogen compound catabolic process | meiotic cell cycle | negative regulation of chromosome organization | negative regulation of molecular function | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | cellular macromolecule localization | positive regulation of triglyceride catabolic process | regulation of nucleosome density | positive regulation of DNA metabolic process | kinase activity | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | 7-methylguanosine RNA capping | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | protein localization to cytoskeleton | mitotic spindle assembly | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of lipid metabolic process | meiotic DNA double-strand break processing | regulation of filamentous growth | cellular metabolic process | mRNA processing | negative regulation of cell cycle process | regulation of protein localization | regulation of organelle assembly | spindle organization | mitotic sister chromatid segregation | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of gene expression | regulation of glycogen metabolic process | macromolecule metabolic process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | catalytic complex | cellular bud neck | microtubule organizing center | cytoplasmic stress granule | protein kinase complex | cell | ribonucleoprotein granule | microtubule | cytoplasm | cytoplasmic microtubule | spindle | intracellular organelle | ribosome | endoplasmic reticulum | protein-containing complex | endomembrane system | cellular bud | ribonucleoprotein complex | transferase complex | aster | microtubule cytoskeleton | site of polarized growth | spindle microtubule | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | spindle pole body | cyclin-dependent protein kinase holoenzyme complex | astral microtubule | cytoskeleton | intracellular | supramolecular complex
