QuickView for CDKN4;jsessionid=1D3DEFA3C387676870F4F5C13A6A2E4D;jsessionid=2376FA8C58AA38E25CF6953E50C805A6 (gene)
- Gene Symbol:
- Cdkn1b
Mus musculus - Full name:
- cyclin-dependent kinase inhibitor 1B
- Synonyms:
- AA408329, AI843786, Kip1, p27, p27Kip1, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27
- Genomic Location:
- Chr 6: 134870435-134874076
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-148 , Predicted Gene Targets for miR-186 , Predicted Gene Targets for miR-190 , Predicted Gene Targets for miR-194 , Predicted Gene Targets for miR-196 , Predicted Gene Targets for miR-221 , Predicted Gene Targets for miR-24 , Predicted Gene Targets for miR-323 , Predicted Gene Targets for miR-455
GO Molecular Function
kinase binding | protein kinase regulator activity | cyclin binding | protein serine/threonine kinase inhibitor activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | protein-containing complex binding | enzyme inhibitor activity | cyclin-dependent protein kinase activity | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | chaperone binding | Hsp70 protein binding | protein binding | protein phosphatase binding | kinase inhibitor activity | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | enzyme regulator activity | kinase activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | phosphatase binding | heat shock protein binding | cyclin-dependent protein serine/threonine kinase regulator activity
GO Biological Process
positive regulation of cyclin-dependent protein serine/threonine kinase activity | negative regulation of phosphorylation | regulation of supramolecular fiber organization | Notch signaling pathway | regulation of cell cycle process | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | developmental process involved in reproduction | regulation of localization | protein kinase regulator activity | regulation of epithelial cell proliferation involved in prostate gland development | regulation of programmed cell death | establishment of localization | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of RNA biosynthetic process | response to metal ion | protein serine/threonine kinase inhibitor activity | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | regulation of organelle organization | response to antibiotic | sensory perception of mechanical stimulus | cellular process | positive regulation of microtubule polymerization | localization | regulation of exit from mitosis | metal ion transport | kinase regulator activity | reproductive system development | response to estradiol | regulation of mitotic nuclear division | protein kinase inhibitor activity | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | positive regulation of cyclin-dependent protein kinase activity | positive regulation of cellular protein metabolic process | cellular response to metal ion | response to stimulus | enzyme inhibitor activity | cellular response to lithium ion | cyclin-dependent protein kinase activity | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | response to stress | negative regulation of protein kinase activity | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | response to glucose | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | programmed cell death | reproduction | cellular response to inorganic substance | cell cycle G1/S phase transition | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | molecular function regulator | regulation of nucleic acid-templated transcription | response to nitrogen compound | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | reproductive process | positive regulation of organelle organization | negative regulation of growth | negative regulation of phosphate metabolic process | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | phosphorus metabolic process | response to amino acid | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | regulation of gene expression | response to lipid | nervous system process | cell cycle | negative regulation of cyclin-dependent protein serine/threonine kinase activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | monovalent inorganic cation transport | negative regulation of smooth muscle cell proliferation | regulation of nitrogen compound metabolic process | negative regulation of protein serine/threonine kinase activity | positive regulation of protein complex assembly | regulation of cellular component movement | response to lithium ion | potassium ion transport | response to cadmium ion | regulation of cellular protein metabolic process | phosphorylation | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | sensory perception of sound | positive regulation of cytoskeleton organization | regulation of protein metabolic process | inner ear development | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of lens fiber cell differentiation | negative regulation of vascular smooth muscle cell proliferation | negative regulation of cell growth | regulation of mitotic cell cycle | regulation of microtubule-based process | positive regulation of molecular function | autophagic cell death | negative regulation of cyclin-dependent protein kinase activity | negative regulation of epithelial cell proliferation | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | cell cycle arrest | kinase inhibitor activity | regulation of kinase activity | cyclin-dependent protein serine/threonine kinase activity | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | ear development | positive regulation of cell death | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | positive regulation of kinase activity | regulation of phosphate metabolic process | negative regulation of cell cycle | negative regulation of protein metabolic process | sensory perception | negative regulation of molecular function | signaling | mitotic cell cycle arrest | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | cation transport | reproductive structure development | regulation of developmental process | kinase activity | developmental process | cyclin-dependent protein serine/threonine kinase inhibitor activity | regulation of cell growth | cellular protein modification process | negative regulation of cell proliferation | positive regulation of protein polymerization | response to organonitrogen compound | cell cycle phase transition | positive regulation of metabolic process | ion transport | cellular metabolic process | placenta development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | response to carbohydrate | negative regulation of epithelial cell proliferation involved in prostate gland development | negative regulation of cell death | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | endomembrane system | vesicle | transferase complex | endosome | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | Cul4-RING E3 ubiquitin ligase complex | Cul4A-RING E3 ubiquitin ligase complex | cytosol | intracellular vesicle | intracellular
