QuickView for CDW44;jsessionid=34AEB6C2774D8425775CA9649F8DA678;jsessionid=1F6CAF48BEE028F32AF9FBA29DCCA0D9 (gene)
- Gene Symbol:
- Cd44
Rattus norvegicus - Full name:
- CD44 molecule (Indian blood group)
- Synonyms:
- CD44A, METAA, RHAMM, CD44 antigen, CD44 antigen isoform d6-12, CD44 antigen isoform d6-13, CD44 antigen isoform d6-15, Cell surface glycoprotein CD44 (hyaluronate binding protein), ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, PGP-1, PGP-I, extracellular matrix receptor III, hermes antigen, hyaluronate receptor, phagocytic glycoprotein 1, phagocytic glycoprotein I
- Genomic Location:
- Chr 3: 88022960-88110352
- Description:
-
adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cytokine binding | kinase binding | protein kinase binding | transmembrane signaling receptor activity | carboxylic acid binding | enzyme binding | hyaluronic acid binding | transforming growth factor beta receptor binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | anion binding | signaling receptor activity | ion binding | cytokine receptor activity | phosphoprotein binding | protein binding | glycosaminoglycan binding | type II transforming growth factor beta receptor binding | epidermal growth factor receptor binding | growth factor receptor binding | organic acid binding | small molecule binding
GO Biological Process
negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | positive regulation of myeloid cell apoptotic process | response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | regulation of cysteine-type endopeptidase activity | response to nutrient levels | negative regulation of immune system process | response to cytokine | cell motility | regulation of cell morphogenesis | developmental process involved in reproduction | positive regulation of apoptotic process | syncytium formation by plasma membrane fusion | morphogenesis of an epithelium | positive regulation of neutrophil apoptotic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of cysteine-type endopeptidase activity | regulation of immune system process | negative regulation of mature B cell apoptotic process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | cell differentiation | regulation of T cell differentiation | defense response | nervous system development | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | generation of neurons | negative regulation of proteolysis | cellular process | organic substance catabolic process | negative regulation of inflammatory response | localization | epithelial tube morphogenesis | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | neuron development | reproductive system development | carbohydrate derivative catabolic process | positive regulation of heterotypic cell-cell adhesion | renal tubule morphogenesis | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | glycosaminoglycan catabolic process | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | regulation of lymphocyte apoptotic process | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | negative regulation of mononuclear cell proliferation | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | prostate gland epithelium morphogenesis | urogenital system development | nephron tubule morphogenesis | response to stimulus | vasculature development | wound healing, spreading of cells | regulation of regulatory T cell differentiation | cellular response to fibroblast growth factor stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | carboxylic acid catabolic process | leukocyte aggregation | gland morphogenesis | response to stress | regulation of heterotypic cell-cell adhesion | negative regulation of lymphocyte activation | regulation of cell proliferation | negative regulation of alpha-beta T cell proliferation | tube morphogenesis | positive regulation of cell-cell adhesion | reproduction | cardiovascular system development | negative regulation of metabolic process | negative regulation of hemopoiesis | cartilage development | regulation of cell adhesion | kidney development | cell-cell signaling | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell surface receptor signaling pathway involved in cell-cell signaling | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | epiboly | regulation of lymphocyte differentiation | blood vessel development | monocyte aggregation | regulation of cellular response to stress | locomotion | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | ureteric bud development | Wnt signaling pathway | multicellular organism development | negative regulation of catalytic activity | cell migration | syncytium formation | regulation of peptidase activity | inflammatory response to wounding | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | kidney morphogenesis | regulation of intrinsic apoptotic signaling pathway | hyaluronan metabolic process | negative regulation of peptidase activity | wound healing | regulation of T cell activation | regulation of gene expression | kidney epithelium development | negative regulation of CD4-positive, alpha-beta T cell proliferation | response to lipid | branching involved in prostate gland morphogenesis | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | negative regulation of lymphocyte apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of signal transduction by p53 class mediator | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | response to nutrient | morphogenesis of an epithelial sheet | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to cytokine stimulus | negative regulation of B cell apoptotic process | regulation of cellular protein metabolic process | mesonephric epithelium development | response to vitamin A | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | positive regulation of leukocyte apoptotic process | regulation of apoptotic signaling pathway | mesonephros development | regulation of B cell apoptotic process | cytokine receptor activity | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | renal tubule development | negative regulation of cell activation | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | renal system development | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | negative regulation of T cell differentiation | nephron development | wound healing involved in inflammatory response | carboxylic acid metabolic process | positive regulation of molecular function | neuron differentiation | ureteric bud morphogenesis | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | tissue morphogenesis | regulation of hemopoiesis | branching morphogenesis of an epithelial tube | regulation of kinase activity | response to wounding | negative regulation of DNA damage response, signal transduction by p53 class mediator | positive regulation of monocyte aggregation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | cell projection organization | metabolic process | negative regulation of leukocyte proliferation | developmental maturation | negative regulation of programmed cell death | positive regulation of cell death | cell adhesion | regulation of myeloid cell apoptotic process | regulation of response to DNA damage stimulus | neuron projection development | organic substance metabolic process | connective tissue development | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | response to vitamin | nephron morphogenesis | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | prostate gland morphogenesis | cell-cell adhesion | blood vessel maturation | positive regulation of MAPK cascade | morphogenesis of a branching epithelium | regulation of peptidyl-serine phosphorylation | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to organic cyclic compound | cell development | regulation of T cell proliferation | organic acid metabolic process | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | reproductive structure development | regulation of developmental process | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | regulation of cell growth | negative regulation of alpha-beta T cell activation | macrophage fusion | tube development | carbohydrate derivative metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | response to fibroblast growth factor | regulation of lamellipodium morphogenesis | negative regulation of hydrolase activity | positive regulation of metabolic process | regulation of cell projection organization | skeletal system development | negative regulation of lymphocyte proliferation | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | circulatory system development | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | mesonephric tubule development | negative regulation of regulatory T cell differentiation | hyaluronan catabolic process | positive regulation of gene expression | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | cell projection membrane | actin-based cell projection | cell | intrinsic component of membrane | lamellipodium | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | leading edge membrane | apical part of cell | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | plasma membrane | cell leading edge | microvillus | membrane-bounded organelle | macrophage migration inhibitory factor receptor complex | nucleus | organelle | cell periphery | basolateral plasma membrane | cytosol | cell surface | intracellular | membrane | lamellipodium membrane
