QuickView for CFTR;jsessionid=8A36039435537221F176F2DB36DE5457;jsessionid=051A3E3A8FA8A6298D9387114207639A (gene)
- Gene Symbol:
- Cftr
Rattus norvegicus - Full name:
- cystic fibrosis transmembrane conductance regulator
- Synonyms:
- RGD1561193, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, ATP-binding cassette transporter sub-family C member 7, cAMP-dependent chloride channel, channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulator homolog
- Genomic Location:
- Chr 4: 43874562-44040151
- Description:
-
cAMP-activated chloride channel and ATP binding cassette (ABC) transporter involved in intestinal anion secretion
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
ATPase activity, coupled to transmembrane movement of substances | organic anion transmembrane transporter activity | anion transmembrane transporter activity | ATP-gated ion channel activity | intracellularly ATP-gated chloride channel activity | channel regulator activity | passive transmembrane transporter activity | enzyme binding | ribonucleotide binding | transmembrane transporter activity | ligand-gated ion channel activity | nucleotide binding | ion gated channel activity | ion channel inhibitor activity | hydrolase activity | chloride channel activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | chloride channel regulator activity | inorganic anion transmembrane transporter activity | molecular function regulator | catalytic activity | chaperone binding | protein domain specific binding | ATP binding | channel inhibitor activity | chloride transmembrane transporter activity | anion binding | adenyl nucleotide binding | bicarbonate transmembrane transporter activity | nucleoside-triphosphatase activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | chloride channel inhibitor activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | anion channel activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | intracellular ligand-gated ion channel activity | PDZ domain binding | adenyl ribonucleotide binding | channel activity | drug binding | ion channel activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | substrate-specific channel activity | small molecule binding
GO Biological Process
negative regulation of smooth muscle cell apoptotic process | regulation of blood vessel diameter | positive regulation of insulin secretion involved in cellular response to glucose stimulus | cellular response to decreased oxygen levels | exocytosis | response to cytokine | positive regulation of ion transmembrane transporter activity | negative regulation of type B pancreatic cell development | developmental process involved in reproduction | regulation of cellular localization | regulation of cell development | regulation of localization | lipid transport | regulation of programmed cell death | ATPase activity, coupled to transmembrane movement of substances | organic anion transmembrane transporter activity | establishment of localization | regulation of immune system process | response to hormone | anion transmembrane transporter activity | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | respiratory tube development | ATP-gated ion channel activity | male gamete generation | fluid transport | response to drug | cellular chemical homeostasis | intracellularly ATP-gated chloride channel activity | positive regulation of gonad development | regulation of peptide hormone secretion | positive regulation of protein secretion | response to antibiotic | response to organophosphorus | sterol metabolic process | cellular process | secretion | channel regulator activity | localization | cellular homeostasis | cell maturation | passive transmembrane transporter activity | anion transport | multicellular organismal reproductive process | macromolecule localization | negative regulation of apoptotic process | membrane docking | transepithelial transport | response to peptide hormone | regulation of cell differentiation | gamete generation | regeneration | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | organelle localization | hepaticobiliary system development | transmembrane transporter activity | organic cyclic compound metabolic process | positive regulation of cyclic nucleotide-gated ion channel activity | ligand-gated ion channel activity | cellular response to organonitrogen compound | steroid biosynthetic process | regulation of peptide secretion | chloride transmembrane transport | response to stimulus | ion gated channel activity | regulation of chloride transport | respiratory system development | ion channel inhibitor activity | regulation of insulin secretion | positive regulation of immune system process | regulation of blood vessel size | response to stress | germ cell development | alcohol metabolic process | multicellular organismal homeostasis | chloride channel activity | chloride transport | response to peptide | regulation of epithelial cell differentiation | inorganic anion transport | positive regulation of cell activation | reproduction | cellular localization | secretion by cell | organic hydroxy compound transport | response to alcohol | response to temperature stimulus | positive regulation of hormone secretion | cellular response to organic cyclic compound | regulation of protein transport | blood circulation | spermatid differentiation | chloride channel regulator activity | regulation of peptide transport | water transport | inorganic anion transmembrane transporter activity | molecular function regulator | cellular response to forskolin | positive regulation of peptide secretion | water homeostasis | regulation of membrane potential | positive regulation of exocytosis | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | system development | response to oxygen levels | reproductive process | channel inhibitor activity | cellular response to antibiotic | multicellular organism development | chloride transmembrane transporter activity | response to purine-containing compound | membrane hyperpolarization | regulation of insulin secretion involved in cellular response to glucose stimulus | lipid metabolic process | regulation of hormone levels | ion transmembrane transport | regulation of hormone secretion | bicarbonate transmembrane transporter activity | positive regulation of secretion | organic substance transport | response to ketone | cellular response to stress | response to lipid | positive regulation of male gonad development | cellular response to heat | regulation of membrane depolarization | cellular ion homeostasis | regulation of anion channel activity | sterol biosynthetic process | liver development | positive regulation of ion transmembrane transport | cellular response to oxygen levels | transepithelial chloride transport | regulation of mast cell activation | active transmembrane transporter activity | small molecule metabolic process | vesicle-mediated transport | regulation of smooth muscle cell apoptotic process | chloride channel inhibitor activity | ion transmembrane transporter activity | positive regulation of cell differentiation | positive regulation of voltage-gated chloride channel activity | biosynthetic process | regulation of male gonad development | sterol transport | cholesterol biosynthetic process | bicarbonate transport | organic anion transport | lipid biosynthetic process | cholesterol transport | cation homeostasis | cellular response to drug | response to estrogen | positive regulation of anion channel activity | regulation of muscle cell apoptotic process | cellular cation homeostasis | liver regeneration | regulation of intracellular pH | positive regulation of transporter activity | homeostatic process | positive regulation of establishment of protein localization | regulation of tube size | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of epithelial cell differentiation | transepithelial water transport | positive regulation of molecular function | multicellular organism reproduction | regulation of establishment of protein localization | response to organic substance | gland development | positive regulation of insulin secretion | epithelial fluid transport | regulation of pH | anion transmembrane transport | regulation of exocytosis | cellular response to anoxia | anatomical structure development | vasodilation | metabolic process | lipid localization | positive regulation of cell development | anion channel activity | positive regulation of leukocyte activation | developmental maturation | cholesterol metabolic process | regulation of body fluid levels | regulation of type B pancreatic cell development | negative regulation of programmed cell death | regulation of tube diameter | regulation of vesicle-mediated transport | negative regulation of muscle cell apoptotic process | negative regulation of vascular associated smooth muscle cell apoptotic process | chemical homeostasis | regulation of secretion | positive regulation of inorganic anion transmembrane transport | positive regulation of mast cell activation | organic substance metabolic process | animal organ development | positive regulation of ion transport | regulation of cell activation | regulation of protein secretion | response to heat | ion homeostasis | cellular response to cAMP | spermatid development | vesicle docking | regulation of ion transmembrane transport | regulation of cellular pH | response to cAMP | lung development | positive regulation of protein transport | steroid metabolic process | intracellular pH elevation | regulation of cell communication | transmembrane transport | sperm capacitation | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | cell development | intracellular ligand-gated ion channel activity | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | channel activity | vesicle docking involved in exocytosis | regulation of developmental process | regulation of ion transport | positive regulation of establishment of Sertoli cell barrier | iodide transport | developmental process | positive regulation of anion transport | spermatogenesis | positive regulation of epithelial cell differentiation | tube development | regulation of transport | multicellular organismal water homeostasis | response to organonitrogen compound | regulation of cyclic nucleotide-gated ion channel activity | regulation of anion transport | ion channel activity | response to anoxia | ion transport | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | negative regulation of cell development | positive regulation of blood vessel diameter | aging | substrate-specific channel activity | sexual reproduction | negative regulation of cell differentiation | positive regulation of signaling | regulation of signaling | animal organ regeneration | multicellular organismal process
GO Cellular Component
rough endoplasmic reticulum membrane | integral component of membrane | dendrite | intracellular membrane-bounded organelle | early endosome membrane | apical plasma membrane | neuron projection | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell body | actin-based cell projection | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | apical part of cell | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | recycling endosome | endomembrane system | endoplasmic reticulum membrane | plasma membrane | endoplasmic reticulum Sec complex | chloride channel complex | vesicle | integral component of plasma membrane | endosome | microvillus | membrane-bounded organelle | nucleus | organelle | recycling endosome membrane | vesicle membrane | cell periphery | early endosome | basolateral plasma membrane | transmembrane transporter complex | ion channel complex | rough endoplasmic reticulum | cytosol | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
