QuickView for COMT;jsessionid=116644BEF111B920349E43C7A53A9700;jsessionid=B9F8A89D2D3AA9728E49D3437BF5E13F (gene)
- Gene Symbol:
- Comt
Rattus norvegicus - Full name:
- catechol-O-methyltransferase
- Synonyms:
- catechol O-methyltransferase, catecholamine-O-methyltransferase
- Genomic Location:
- Chr 11: 84576767-84599229
- Description:
-
catalyzes the conversion of S-adenosyl-L-methionine and catechol to S-adenosyl-L-homocysteine and guaiacol
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
GO Molecular Function
catechol O-methyltransferase activity | cation binding | magnesium ion binding | S-adenosylmethionine-dependent methyltransferase activity | L-dopa O-methyltransferase activity | catalytic activity | O-methyltransferase activity | ion binding | transferase activity | methyltransferase activity | metal ion binding | orcinol O-methyltransferase activity
GO Biological Process
response to extracellular stimulus | response to nutrient levels | response to lipopolysaccharide | regulation of localization | sulfur compound metabolic process | catechol-containing compound metabolic process | negative regulation of cellular process | positive regulation of developmental process | cellular response to extracellular stimulus | response to drug | estrogen metabolic process | regulation of renal sodium excretion | catechol O-methyltransferase activity | phenol-containing compound metabolic process | cellular process | organic substance catabolic process | female pregnancy | multicellular organismal reproductive process | learning | catecholamine catabolic process | negative regulation of secretion | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | S-adenosylmethionine metabolic process | regulation of neurological system process | cellular amino acid metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | regulation of sulfur amino acid metabolic process | response to pain | regulation of excretion | response to stress | regulation of cell proliferation | response to starvation | reproduction | L-dopa O-methyltransferase activity | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of dopamine metabolic process | negative regulation of transport | negative regulation of metabolic process | cofactor metabolic process | purine nucleoside metabolic process | dopamine metabolic process | drug catabolic process | regulation of catecholamine metabolic process | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to external biotic stimulus | cellular response to nutrient levels | nitrogen compound metabolic process | reproductive process | O-methyltransferase activity | learning or memory | lipid metabolic process | regulation of hormone levels | regulation of sensory perception of pain | S-adenosylhomocysteine metabolic process | dopamine catabolic process | positive regulation of secretion | methylation | regulation of cellular amino acid metabolic process | cellular response to stress | response to lipid | nervous system process | nucleoside metabolic process | positive regulation of cellular metabolic process | negative regulation of smooth muscle cell proliferation | regulation of nitrogen compound metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | cognition | neurotransmitter metabolic process | cellular response to phosphate starvation | neurotransmitter catabolic process | response to bacterium | response to estrogen | cell communication | regulation of cellular metabolic process | regulation of lactation | regulation of homocysteine metabolic process | short-term memory | aromatic compound catabolic process | positive regulation of homocysteine metabolic process | positive regulation of transport | drug metabolic process | carboxylic acid metabolic process | multicellular organism reproduction | multicellular organismal response to stress | response to organic substance | catecholamine metabolic process | negative regulation of dopamine metabolic process | metabolic process | regulation of body fluid levels | regulation of secretion | behavior | nucleobase-containing compound metabolic process | organic substance metabolic process | memory | organonitrogen compound catabolic process | steroid metabolic process | response to organic cyclic compound | organic acid metabolic process | hormone metabolic process | response to biotic stimulus | regulation of cellular ketone metabolic process | regulation of developmental process | methyltransferase activity | developmental process | carbohydrate derivative metabolic process | regulation of transport | negative regulation of cell proliferation | cellular modified amino acid metabolic process | heterocycle metabolic process | positive regulation of lactation | positive regulation of metabolic process | cellular metabolic process | negative regulation of renal sodium excretion | regulation of smooth muscle cell proliferation | orcinol O-methyltransferase activity | response to other organism | multicellular organismal process
GO Cellular Component
dendritic spine | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | dendritic tree | glial cell projection | cell projection | postsynaptic membrane | neuron spine | postsynapse | plasma membrane | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | axon | cytosol | intracellular | membrane
