QuickView for CVAP;jsessionid=0D89EADF7072BEB6E02804F41BA302BA;jsessionid=562899FF62DD4EED5DE9EFF22EAFCAC8 (gene)
- Gene Symbol:
- App
Mus musculus - Full name:
- amyloid beta (A4) precursor protein
- Synonyms:
- Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, amyloid-beta A4 protein, amyloid beta A4 protein, alzheimer disease amyloid A4 protein homolog, amyloid precursor protein, amyloid-beta precursor protein, amyloidogenic glycoprotein, appican, beta-amyloid precursor protein, protease nexin II
- Genomic Location:
- Chr 16: 84954688-85173948
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AAANWWTGC_UNKNOWN , AACTTT_UNKNOWN , EGR1_01 , NGFIC_01 , AREB6_03 , PITX2_Q2 , CTGCAGY_UNKNOWN , ERR1_Q2 , FXR_Q3 , TCF1P_Q6
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-153 , Predicted Gene Targets for miR-185 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-324-5p , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-383 , Predicted Gene Targets for miR-93
| Transcripts Names |
|---|
| NM_007471 |
| NM_001198823 |
| NM_001198824 |
| NM_001198825 |
| NM_001198826 |
| XM_006522874 |
| XM_006522873 |
GO Molecular Function
endopeptidase inhibitor activity | enzyme activator activity | cation binding | PTB domain binding | enzyme binding | nucleic acid binding | peptidase activator activity | enzyme inhibitor activity | signaling receptor binding | carbohydrate derivative binding | molecular function regulator | protein domain specific binding | anion binding | DNA binding | identical protein binding | ion binding | organic cyclic compound binding | heparin binding | protein binding | glycosaminoglycan binding | transition metal ion binding | serine-type endopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | growth factor receptor binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | axon choice point recognition | regulation of ERK1 and ERK2 cascade | brain development | regulation of supramolecular fiber organization | Notch signaling pathway | protein homooligomerization | response to radiation | cell morphogenesis | regulation of cell cycle process | positive regulation of amyloid precursor protein catabolic process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | endopeptidase inhibitor activity | microtubule-based transport | extracellular structure organization | RNA processing | positive regulation of cellular component organization | regulation of neurogenesis | neuron projection morphogenesis | enzyme activator activity | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | modulation of age-related behavioral decline | positive regulation of peptidyl-threonine phosphorylation | establishment of localization | regulation of immune system process | myeloid cell differentiation | astrocyte development | neuron death | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | regulation of spontaneous synaptic transmission | positive regulation of phosphate metabolic process | collateral sprouting in absence of injury | positive regulation of cellular component movement | generation of neurons | intracellular transport | microtubule-based process | negative regulation of proteolysis | neuromuscular process controlling balance | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | astrocyte activation involved in immune response | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | positive regulation of synaptic transmission | cell maturation | developmental growth | visual learning | neuron projection maintenance | positive regulation of peptidyl-serine phosphorylation | neuron development | regulation of neuronal synaptic plasticity | cellular response to norepinephrine stimulus | synapse assembly | positive regulation of macrophage activation | immune system development | multicellular organismal reproductive process | learning | axon guidance | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | myeloid cell development | copper ion homeostasis | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of neurological system process | regulation of cell differentiation | cytoskeleton-dependent intracellular transport | cell recognition | regulation of cellular process | regulation of metabolic process | gliogenesis | positive regulation of stress-activated MAPK cascade | peptidase activator activity | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | calcium ion homeostasis | positive regulation of protein binding | head development | positive regulation of stress-activated protein kinase signaling cascade | associative learning | response to stimulus | enzyme inhibitor activity | cell morphogenesis involved in neuron differentiation | positive regulation of NIK/NF-kappaB signaling | regulation of mitotic cell cycle phase transition | regulation of long-term synaptic potentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | neuron projection guidance | positive regulation of T cell migration | posttranscriptional regulation of gene expression | alcohol metabolic process | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | positive regulation of long-term synaptic potentiation | tumor necrosis factor production | programmed cell death | supramolecular fiber organization | positive regulation of cell activation | microtubule-based movement | reproduction | cellular localization | positive regulation of proteolysis | macrophage differentiation | cellular nitrogen compound metabolic process | extracellular matrix organization | positive regulation of gliogenesis | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | mRNA metabolic process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | macromolecule modification | mRNA polyadenylation | molecular function regulator | metal ion homeostasis | regulation of nucleic acid-templated transcription | regulation of membrane potential | leukocyte differentiation | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | response to nitrogen compound | regulation of long-term neuronal synaptic plasticity | apoptotic process | regulation of cell cycle G2/M phase transition | response to light stimulus | regulation of protein tyrosine kinase activity | RNA polyadenylation | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | smooth endoplasmic reticulum calcium ion homeostasis | modulation of excitatory postsynaptic potential | astrocyte activation | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | learning or memory | protein complex oligomerization | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | positive regulation of astrocyte activation | amyloid fibril formation | positive regulation of lymphocyte migration | negative regulation of peptidase activity | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of neuron differentiation | regulation of gene expression | axon development | nervous system process | cellular response to peptide | neuron recognition | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | neuromuscular junction development | cellular ion homeostasis | adult locomotory behavior | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | neuron apoptotic process | small molecule metabolic process | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | response to oxidative stress | synapse organization | axonogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | cognition | synaptic growth at neuromuscular junction | positive regulation of cell migration | neuron remodeling | locomotory behavior | cellular copper ion homeostasis | regulation of cellular protein metabolic process | glial cell differentiation | phosphorylation | protein phosphorylation | regulation of amyloid precursor protein catabolic process | cell morphogenesis involved in differentiation | cation homeostasis | regulation of leukocyte migration | phosphate-containing compound metabolic process | regulation of macrophage activation | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of T cell migration | response to catecholamine | astrocyte differentiation | cell activation involved in immune response | cellular response to amyloid-beta | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | suckling behavior | regulation of locomotion | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of amyloid fibril formation | neuron maturation | positive regulation of molecular function | neuron differentiation | multicellular organism reproduction | cytokine production | regulation of signaling receptor activity | response to monoamine | regulation of epidermal growth factor-activated receptor activity | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | visual behavior | regulation of kinase activity | import into cell | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | developmental growth involved in morphogenesis | positive regulation of mitotic cell cycle phase transition | cell surface receptor signaling pathway | positive regulation of neurogenesis | reproductive behavior | cell projection organization | metabolic process | positive regulation of cell development | positive regulation of supramolecular fiber organization | RNA 3'-end processing | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of long-term synaptic potentiation | developmental maturation | cholesterol metabolic process | regulation of amyloid fibril formation | transport along microtubule | mating behavior | collateral sprouting | positive regulation of glial cell differentiation | chemical homeostasis | endocytosis | behavior | cell adhesion | immune response | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | mating | regulation of epidermal growth factor receptor signaling pathway | cell death | negative regulation of gene expression | animal organ development | forebrain development | negative regulation of neuron differentiation | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | ion homeostasis | regulation of phosphate metabolic process | positive regulation of astrocyte differentiation | positive regulation of binding | axon midline choice point recognition | serine-type endopeptidase inhibitor activity | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | regulation of peptidyl-serine phosphorylation | memory | adult behavior | negative regulation of protein metabolic process | steroid metabolic process | response to norepinephrine | regulation of glial cell differentiation | regulation of stress-activated MAPK cascade | regulation of cell communication | axo-dendritic transport | regulation of gliogenesis | negative regulation of molecular function | signaling | feeding behavior | response to amyloid-beta | regulation of transcription, DNA-templated | regulation of protein binding | glial cell development | response to organic cyclic compound | regulation of amyloid-beta formation | neuromuscular process | cell development | regulation of ERBB signaling pathway | regulation of developmental growth | positive regulation of phosphorylation | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | anatomical structure morphogenesis | regulation of endopeptidase activity | glutamate receptor signaling pathway | dendrite development | regulation of nervous system development | regulation of developmental process | positive regulation of microglial cell activation | endoplasmic reticulum calcium ion homeostasis | developmental process | microglia development | positive regulation of cell cycle process | cellular protein modification process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | developmental cell growth | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of hydrolase activity | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | transition metal ion homeostasis | mRNA 3'-end processing | regulation of microglial cell activation | immune system process | cellular metabolic process | long-term synaptic potentiation | mRNA processing | hematopoietic or lymphoid organ development | positive regulation of amyloid-beta formation | cellular response to organic substance | regulation of astrocyte differentiation | positive regulation of cell motility | regulation of translation | ionotropic glutamate receptor signaling pathway | negative regulation of cell development | aging | chemotaxis | divalent inorganic cation homeostasis | sexual reproduction | regulation of lymphocyte migration | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | synapse | neuron projection | neuromuscular junction | cytoplasmic vesicle | actin-based cell projection | cell | growth cone filopodium | COPII-coated ER to Golgi transport vesicle | distal axon | intrinsic component of membrane | lamellipodium | cytoplasm | spindle | intracellular organelle | receptor complex | endoplasmic reticulum | membrane microdomain | main axon | apical part of cell | cell-cell junction | glial cell projection | nuclear envelope lumen | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | plasma membrane | nuclear envelope | Golgi-associated vesicle | cell leading edge | cilium | membrane raft | vesicle | perinuclear region of cytoplasm | clathrin-coated pit | microtubule cytoskeleton | site of polarized growth | ciliary rootlet | spindle midzone | endosome | extracellular region | growth cone lamellipodium | membrane-bounded organelle | astrocyte projection | filopodium | nucleus | organelle | extracellular space | cell periphery | axon | membrane-enclosed lumen | growth cone | rough endoplasmic reticulum | intracellular vesicle | cell surface | cytoskeleton | intracellular | cell junction | membrane | coated vesicle
