QuickView for CX3CR1;jsessionid=F22B1524D83792BC5FC5B755AC561D6A;jsessionid=AC7B67C5BE359DC8BB395FFBA5A5BC7D (gene)
- Gene Symbol:
- Cx3cr1
Rattus norvegicus - Full name:
- C-X3-C motif chemokine receptor 1
- Synonyms:
- Rbs11, CX3C chemokine receptor 1, C-X3-C CKR-1, chemokine (C-X3-C motif) receptor 1, chemokine (C-X3-C) receptor 1, fractalkine receptor
- Genomic Location:
- Chr 8: 125033630-125047335
- Description:
-
member of the rhodopsin family of G-protein coupled receptors; may act as a receptor for a chemokine peptide ligand
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cytokine binding | C-X3-C chemokine receptor activity | transmembrane signaling receptor activity | G-protein coupled receptor activity | chemokine binding | C-X3-C chemokine binding | signaling receptor activity | G-protein coupled chemoattractant receptor activity | cytokine receptor activity | protein binding | C-C chemokine receptor activity | peptide receptor activity | chemokine receptor activity | G-protein coupled peptide receptor activity | C-C chemokine binding
GO Biological Process
brain development | regulation of extrinsic apoptotic signaling pathway in absence of ligand | macrophage chemotaxis | macrophage migration | response to cytokine | cell motility | regulation of neurogenesis | response to lipopolysaccharide | intracellular signal transduction | autocrine signaling | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | chemokine-mediated signaling pathway | nervous system development | negative regulation of hippocampal neuron apoptotic process | cellular chemical homeostasis | negative regulation of chronic inflammatory response to non-antigenic stimulus | neurogenesis | positive regulation of phosphate metabolic process | negative regulation of chronic inflammatory response | generation of neurons | regulation of neuroblast proliferation | regulation of neuron death | cellular process | C-X3-C chemokine receptor activity | negative regulation of inflammatory response | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cellular homeostasis | forebrain cell migration | negative regulation of signaling | negative regulation of apoptotic process | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of cell differentiation | negative regulation of apoptotic signaling pathway | negative regulation of cell motility | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | leukocyte tethering or rolling | regulation of metabolic process | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | calcium ion homeostasis | response to transforming growth factor beta | head development | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | positive regulation of I-kappaB phosphorylation | regulation of long-term synaptic potentiation | positive regulation of protein metabolic process | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | positive regulation of neuroblast proliferation | negative regulation of angiogenesis | telencephalon cell migration | response to molecule of bacterial origin | response to ischemia | G-protein coupled receptor signaling pathway | modulation of chemical synaptic transmission | cell-cell signaling | microglial cell activation involved in immune response | cell chemotaxis | metal ion homeostasis | leukocyte migration | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | locomotion | negative regulation of neuron apoptotic process | response to external biotic stimulus | system development | regulation of signal transduction | multicellular organism development | cell migration | learning or memory | positive regulation of protein kinase B signaling | regulation of phosphorylation | telencephalon development | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | response to lipid | nervous system process | regulation of stem cell proliferation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | G-protein coupled chemoattractant receptor activity | positive regulation of cell differentiation | second-messenger-mediated signaling | negative regulation of extrinsic apoptotic signaling pathway | cognition | macrophage activation involved in immune response | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulation of apoptotic signaling pathway | microglial cell activation | cerebral cortex cell migration | regulation of tumor necrosis factor production | cation homeostasis | cytokine receptor activity | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | cerebral cortex development | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | calcium-mediated signaling | positive regulation of protein modification process | response to organic substance | leukocyte adhesion to vascular endothelial cell | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | regulation of chronic inflammatory response | leukocyte cell-cell adhesion | positive regulation of cell development | regulation of RNA biosynthetic process | negative regulation of long-term synaptic potentiation | negative regulation of programmed cell death | chemical homeostasis | behavior | cell adhesion | macrophage activation | immune response | regulation of tumor necrosis factor biosynthetic process | animal organ development | forebrain development | pallium development | negative regulation of cellular component movement | positive regulation of NF-kappaB transcription factor activity | ion homeostasis | regulation of phosphate metabolic process | phospholipase C-activating G-protein coupled receptor signaling pathway | cell-cell adhesion | cell activation | regulation of reactive oxygen species biosynthetic process | memory | C-C chemokine receptor activity | regulation of cell communication | negative regulation of signal transduction | chemokine receptor activity | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | G-protein coupled peptide receptor activity | regulation of transcription, DNA-templated | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of stem cell proliferation | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | developmental process | cellular extravasation | regulation of reactive oxygen species metabolic process | negative regulation of vasculature development | cellular metal ion homeostasis | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | immune system process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | regulation of inflammatory response | chemotaxis | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of angiogenesis | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | nuclear lumen | neuronal cell body | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | dendritic tree | cell projection | nucleoplasm | plasma membrane | neuronal cell body membrane | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cell periphery | cell body membrane | membrane-enclosed lumen | cell surface | intracellular | membrane
