QuickView for CYP17A1;jsessionid=8C678FAD5387236AAC9F7B0A0B8BE8CE;jsessionid=9D46816B91C909AAB991C13AFC0D5231 (gene)
- Gene Symbol:
- Cyp17a1
Rattus norvegicus - Full name:
- cytochrome P450, family 17, subfamily a, polypeptide 1
- Synonyms:
- Cyp17, steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450, subfamily XVII, P450-C17, P45017alpha, P450c17, cytochrome P450 17A1, cytochrome P450, subfamily 17, cytochrome P450-C17, cytochrome P450c17
- Genomic Location:
- Chr 1: 251965454-251971449
- Description:
-
steroid hydroxylase that comprises a main component of the steroidogenic pathway; activity culminates in corticosteriod and androgen production in adrenal gland and sex steroid production in gonads
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | lyase activity | carbon-carbon lyase activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | aldehyde-lyase activity | ion binding | organic cyclic compound binding | 17-alpha-hydroxyprogesterone aldolase activity | steroid 17-alpha-monooxygenase activity | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity
GO Biological Process
response to extracellular stimulus | brain development | response to radiation | positive regulation of hormone biosynthetic process | response to nutrient levels | response to cytokine | response to lipopolysaccharide | developmental process involved in reproduction | positive regulation of steroid hormone biosynthetic process | gonad development | hippocampus development | response to hormone | cell differentiation | nervous system development | response to drug | benzene-containing compound metabolic process | response to antibiotic | phenol-containing compound metabolic process | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | Leydig cell differentiation | regulation of steroid hormone biosynthetic process | dicarboxylic acid metabolic process | reproductive system development | multicellular organismal reproductive process | gamete generation | regulation of cellular process | cellular response to lipid | regulation of metabolic process | xenobiotic metabolic process | steroid hydroxylase activity | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | development of primary sexual characteristics | head development | response to stimulus | ovulation | female gamete generation | cellular response to xenobiotic stimulus | response to stress | positive regulation of lipid biosynthetic process | androgen biosynthetic process | reproduction | androgen metabolic process | response to molecule of bacterial origin | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of steroid metabolic process | response to herbicide | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | system development | reproductive process | cellular response to antibiotic | multicellular organism development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | antibiotic metabolic process | hormone biosynthetic process | response to purine-containing compound | response to methylmercury | lipid metabolic process | regulation of hormone levels | telencephalon development | response to lipid | cellular response to gonadotropin stimulus | positive regulation of cellular metabolic process | dibenzo-p-dioxin metabolic process | small molecule metabolic process | positive regulation of steroid metabolic process | cellular ketone metabolic process | biosynthetic process | response to acetate | regulation of hormone metabolic process | phthalate metabolic process | lipid biosynthetic process | response to toxic substance | response to xenobiotic stimulus | endocrine system development | response to bacterium | regulation of cellular metabolic process | limbic system development | response to retinoic acid | regulation of lipid biosynthetic process | steroid 17-alpha-monooxygenase activity | response to insecticide | drug metabolic process | carboxylic acid metabolic process | multicellular organism reproduction | development of primary male sexual characteristics | response to organic substance | gland development | progesterone metabolic process | male sex differentiation | positive regulation of steroid biosynthetic process | biphenyl metabolic process | anatomical structure development | metabolic process | oxidation-reduction process | male gonad development | adrenal gland development | organic substance metabolic process | animal organ development | forebrain development | pallium development | C21-steroid hormone metabolic process | response to gonadotropin | response to cAMP | response to fungicide | steroid metabolic process | glucocorticoid metabolic process | response to organic cyclic compound | organic acid metabolic process | hormone metabolic process | response to biotic stimulus | reproductive structure development | developmental process | glucocorticoid biosynthetic process | response to organonitrogen compound | heterocycle metabolic process | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | sex differentiation | oxidoreductase activity | response to steroid hormone | sexual reproduction | response to ionizing radiation | response to other organism | regulation of hormone biosynthetic process | cellular response to lipopolysaccharide | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | cell projection | endomembrane system | membrane-bounded organelle | organelle | axon | intracellular | membrane
