QuickView for CYP1B1;jsessionid=3953E34A356F416CB15FC0085D20B0B2;jsessionid=2A57CC5D28963498F55BAEFE5E06AEA1;jsessionid=E1215EEE49586831C4BE0D45548B777E;jsessionid=0F261020DE34FF4595A18F5DFB33450D (gene)

Gene Symbol:

CYP1B1 Homo sapiens

Full name:

cytochrome P450 family 1 subfamily B member 1

Synonyms:

ASGD6, CP1B, CYPIB1, GLC3A, P4501B1, cytochrome P450 1B1, aryl hydrocarbon hydroxylase, cytochrome P450, family 1, subfamily B, polypeptide 1, cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile), flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase

Genomic Location:

Chr 2: 38148250-38156796

Description:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as pol...

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCTGTGA_MIR513 ,  CAGGTG_E12_Q6 ,  AHR_Q5 ,  YGCGYRCGC_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CTTTGT_LEF1_Q2 ,  RRCCGTTA_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-27

miRNA binding sites
(Source: miRecords):

hsa-miR-27b Targeted Genes ,  hsa-miR-124 Targeted Genes

Cytogenetic Map:

2p22.2

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