QuickView for CYP2D6;jsessionid=4BCE308953C43C10A5907D75F6F01E99;jsessionid=37D5A0C45487F21718E2C444A3DF8D74 (gene)
- Gene Symbol:
- Cyp2d4
Rattus norvegicus - Full name:
- cytochrome P450, family 2, subfamily d, polypeptide 4
- Synonyms:
- Cyp2d18, Cyp2d22, Cyp2d4v1, Cyp2d4v2, Cyp2d6, cytochrome P450 2D4, CYPIID18, CYPIID4, Cytochrome P450, subfamily IID4, P450 2D-29/2D-35, P450-CMF3, P450-DB4, cytochrome P450 2D-29, cytochrome P450 2D-35, cytochrome P450 2d18, cytochrome P450, family 2, subfamily d, polypeptide 22, cytochrome P450, subfamily 2D, polypeptide 6, cytochrome P450, subfamily IID, polypeptide 6, cytochrome P450-CMF3, cytochrome P450-DB4, debrisoquine 4-hydroxylase
- Genomic Location:
- Chr 7: 120741304-120752272
- Description:
-
has N-demethylation activity toward the antidepressant imipramine
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NFKAPPAB65_01 , CREL_01 , MYCMAX_01 , MAX_01 , CEBP_01 , USF_C , MYCMAX_B , MYCMAX_03 , NFAT_Q4_01 , CACGTG_MYC_Q2
GO Molecular Function
cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | tetrapyrrole binding | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity
GO Biological Process
catechol-containing compound metabolic process | negative regulation of cellular process | response to drug | phenol-containing compound metabolic process | cellular process | organic substance catabolic process | alkaloid metabolic process | aromatic amino acid family metabolic process | female pregnancy | negative regulation of cellular metabolic process | regulation of binding | cellular amino acid metabolic process | cellular biogenic amine metabolic process | regulation of cellular process | regulation of metabolic process | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular lipid metabolic process | response to stimulus | serotonin metabolic process | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | serotonin biosynthetic process from tryptophan | cellular nitrogen compound biosynthetic process | reproduction | cellular nitrogen compound metabolic process | negative regulation of cellular organofluorine metabolic process | catecholamine biosynthetic process | negative regulation of metabolic process | amine metabolic process | cellular biosynthetic process | dopamine metabolic process | drug catabolic process | alkaloid catabolic process | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | nitrogen compound metabolic process | reproductive process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | regulation of hormone levels | small molecule metabolic process | dopamine biosynthetic process | exogenous drug catabolic process | negative regulation of binding | neurotransmitter metabolic process | biosynthetic process | aromatic compound biosynthetic process | response to xenobiotic stimulus | oxidative demethylation | regulation of cellular metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | long-chain fatty acid metabolic process | arachidonic acid monooxygenase activity | drug metabolic process | carboxylic acid metabolic process | monoterpenoid metabolic process | response to organic substance | catecholamine metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | C21-steroid hormone metabolic process | fatty acid metabolic process | organonitrogen compound catabolic process | icosanoid metabolic process | steroid metabolic process | neurotransmitter biosynthetic process | coumarin metabolic process | negative regulation of molecular function | organic acid metabolic process | hormone metabolic process | isoprenoid metabolic process | serotonin biosynthetic process | isoquinoline alkaloid metabolic process | indole-containing compound biosynthetic process | heterocycle metabolic process | demethylation | tryptophan metabolic process | cellular metabolic process | oxidoreductase activity | aromatase activity | arachidonic acid metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | mitochondrion | membrane-bounded organelle | organelle | intracellular | membrane
