QuickView for CYP2E1;jsessionid=14C92C062A932B147A76FD916FCFA26F;jsessionid=DDC9ABA23489B69CA8C24E3AA2D5EDED (gene)
- Gene Symbol:
- Cyp2e1
Rattus norvegicus - Full name:
- cytochrome P450, family 2, subfamily e, polypeptide 1
- Synonyms:
- Cyp2e, cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, P450-J, P450RLM6, cytochrome P450 subfamily 2e1 (ethanol-inducible), cytochrome P450, subfamily 2E, polypeptide 1, cytochrome P450-J, cytochrome P450RLM6
- Genomic Location:
- Chr 1: 200918521-200928919
- Description:
-
facilitates hepatocyte sensitization to tumor necrosis factor-alpha (TNF-alpha)-mediated cell death; may play a role in xenobiotic metabolism
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
RSRFC4_01 , HNF1_01 , ARP1_01 , RSRFC4_Q2 , TCF4_Q5 , HNF1_Q6 , LEF1_Q2 , YAATNANRNNNCAG_UNKNOWN , CTTTGA_LEF1_Q2 , CTAWWWATA_RSRFC4_Q2
GO Molecular Function
cofactor binding | cation binding | enzyme binding | ribonucleotide binding | steroid hydroxylase activity | FMN binding | nucleotide binding | iron ion binding | coenzyme binding | carbohydrate derivative binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | anion binding | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | tetrapyrrole binding | protein binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding | arachidonic acid epoxygenase activity
GO Biological Process
response to drug | response to antibiotic | cellular process | triglyceride metabolic process | response to inorganic substance | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | cellular lipid metabolic process | response to stimulus | cellular response to xenobiotic stimulus | response to stress | response to ozone | response to alcohol | drug catabolic process | response to ethanol | response to nitrogen compound | response to external biotic stimulus | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | small molecule metabolic process | response to oxidative stress | exogenous drug catabolic process | response to toxic substance | response to xenobiotic stimulus | response to bacterium | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | glycerolipid metabolic process | arachidonic acid monooxygenase activity | drug metabolic process | monoterpenoid metabolic process | response to organic substance | neutral lipid metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | response to reactive oxygen species | steroid metabolic process | organic acid metabolic process | response to biotic stimulus | isoprenoid metabolic process | response to organonitrogen compound | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity | acylglycerol metabolic process | response to other organism | arachidonic acid epoxygenase activity
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | mitochondrion | Golgi membrane | membrane-bounded organelle | organelle | intracellular | membrane
