QuickView for CYP3A4;jsessionid=D84FCBDF339559051E108AA5C83DA470;jsessionid=100DD612A46FD7B4F290392B46C2A8A9 (gene)
- Gene Symbol:
- Cyp3a23/3a1
Rattus norvegicus - Full name:
- cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1
- Synonyms:
- CYP, CYP3A23, Cyp3a1, Cyp3a3, RL33, cDEX, cytochrome P450 3A1, CYPIIIA1, Cytochrome P450, subfamily IIIA, polypeptide 3, P450 IIIA, P450-PCN1, cytochrome P-450PCN (PNCN inducible), cytochrome P450, family 3, subfamily a, polypeptide 1, cytochrome P450, subfamily 3A, polypeptide 3, cytochrome P450-PCN1, cytochrome P450/6 beta B
- Genomic Location:
- Chr 12: 9566781-9595971
- Description:
-
steroid-inducible member of p450 subfamily 3A; induced by pregnenolone 16 alpha-carbonitrile, dexamethasone (DEX), phenobarbital (PB) and triacetyloleandomycin
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | demethylase activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | testosterone 6-beta-hydroxylase activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity
GO Biological Process
response to extracellular stimulus | response to nutrient levels | response to hormone | response to metal ion | response to drug | cellular process | response to inorganic substance | steroid hydroxylase activity | response to stimulus | demethylase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | response to lipid | response to corticosteroid | response to nutrient | response to cadmium ion | testosterone 6-beta-hydroxylase activity | oxidative demethylation | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | drug metabolic process | response to organic substance | metabolic process | oxidation-reduction process | response to organic cyclic compound | developmental process | demethylation | cellular metabolic process | oxidoreductase activity | response to steroid hormone | aromatase activity | aging | response to glucocorticoid
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
